Circulating miR-223-3p: A Novel Marker for Early Detection and Glycemic Regulation in Type 2 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Expression levels of circulating miR 223 3p in healthy controls individuals with prediabetes and newly diagnosed T2DM patients and its correlation with glycemic parameters HbA1c fasting blood sugar insulin resistance.
研究概览
简要总结
This study aims to evaluate circulating miR 223 3p as a potential early biomarker for Type 2 Diabetes Mellitus. A total of 85 participants will be enrolled including healthy controls individuals with prediabetes and newly diagnosed T2DM patients. Blood samples will be analyzed for miR 223 3p expression using qRT PCR along with glycemic parameters such as HbA1c fasting blood sugar insulin and inflammatory markers. The study will investigate the association of miR 223 3p with glycemic regulation and insulin resistance. Findings are expected to support early detection improve preventive strategies and contribute to personalized diabetes management.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Body Mass Index (BMI) Between 18 point 5 and 30 kilograms per square meter No history of chronic illnesses such as chronic kidney disease and coronary artery disease and asthma and others (except Type 2 Diabetes Mellitus in the case group) No previous use of hypoglycemic drugs or insulin therapy (for prediabetes and Type 2 Diabetes Mellitus groups).
排除标准
- •Pregnant or lactating women Patients on long term medication affecting glucose metabolism.
结局指标
主要结局
Expression levels of circulating miR 223 3p in healthy controls individuals with prediabetes and newly diagnosed T2DM patients and its correlation with glycemic parameters HbA1c fasting blood sugar insulin resistance.
时间窗: Assessed at baseline by fasting blood sample collection at enrolment
次要结局
未报告次要终点
研究者
VISHWANATH MALKAPPA JALAWADI
BLDE Deemed to be university Shri BM Patil Medical College, Hospital and Research Centre