Pulp regeneration for permanent mature teeth by application of normal scaffolds

Not Applicable

Completed

• Conditions: ecrotic single-rooted permanent straight teeth with mature roots; Oral Health

• Registration Number: ISRCTN44531236
• Lead Sponsor: Damascus University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2024-01-13
• Study Start: 2024-07-08
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Aged between 15-45 years old with necrotic single-rooted permanent straight teeth with mature root
2. Radiographical presence of periapical lesions less than 10 mm in diameter
3. Healthy and free of any systemic diseases
4. Patients with a negative response to the allergic patch test (triple antibiotic paste) were included in the study
5. Willingness to cooperate and commit to work sessions and follow-ups

Exclusion Criteria

1. Teeth that are grossly decayed or fractured which cannot be isolated with the rubber dam and require post and core as final restorations
2. Teeth with previous root canal treatment
3. Teeth with root fracture or with external and internal resorption and teeth with developmental anomalies
4. Patients with generalized chronic periodontitis and the presence of draining sinus
5. Patients with calcified canals, canals with apparent curvature
6. Patients who were allergic to any drugs
7. Patients with systemic disease
8. Pregnancy
9. Patients with a history of major surgeries like cardiac, kidney transplantation, hemodialysis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The condition of the periapical lesion will be measured clinically (spontaneous or palpable pain, soft tissue swelling, or sinus tract) using a vitality test and using radiographical scoring at 1, 3, 6, and 12-month intervals

Secondary Outcome Measures

Name	Time	Method
1. Patient demographic information (age in years and sex) recorded during the patient examination at a baseline visit<br>2. Apex diameter (in mm) and working length (in mm) measured using a 35# k file during the preparation phase