Regulation of bone homeostasis by circulating miRNAs (C-miR) in Yi Bone Broth: a molecular mechanism of osteoporosis

Not Applicable

Recruiting

• Conditions: Osteoporosis

• Registration Number: ITMCTR2024000042
• Lead Sponsor: The Third Affiliated Hospital of Zhejiang Chinese Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Meet the diagnostic criteria and age standards of this project
(2) Inclusion criteria include those who have not taken anti osteoporosis drugs or other treatments within 3 months;
(3) Patients willing to take traditional Chinese medicine decoction for treatment;
(4) Meets normal height/body mass index, physical activity scale (PAS) = 180 points, and has no bad habits;
(5) Sign the informed consent form for clinical research.

Exclusion Criteria

(1) Patients with non primary osteoporosis: 1) endocrine cortisol, hyperthyroidism, primary hyperparathyroidism, acromegaly, hypogonadism, diabetes, etc. 2) Nutritional protein deficiency, vitamin C deficiency, low calcium diet, alcoholism, etc 3) Chromosomal abnormalities in hereditary osteogenesis imperfecta. 4) Liver disease. 5) Hemodialysis for chronic nephritis caused by kidney disease. 6) Medications such as corticosteroids, antiepileptic drugs, anti-tumor drugs (such as methotrexate), heparin, etc Sporadic systemic osteoporosis can be seen in long-term bed rest, paraplegia, space flight, etc; Localized bone atrophy can be seen after fractures, Sudecks bone atrophy, and post injury bone atrophy Gastrectomy for gastrointestinal malabsorption Rheumatoid arthritis Multiple myeloma metastasis, monocytic leukemia, Mast Cell disease, etc Other causes include bone loss, transient or migratory osteoporosis.
(2) Patients with incomplete original data records;
(3) Patients with severe chronic primary diseases such as cardiovascular, cerebrovascular, liver, kidney, respiratory, and hematopoietic systems, as well as mental illness;
(4) Those who have used traditional Chinese medicine to treat osteoporosis in the past month;
(5) Patients with combined fresh fractures and severe multiple fractures;

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone mineral density;

Secondary Outcome Measures

Name	Time	Method
Traditional Chinese Medicine Syndrome Score;miRNA;