Diaphragm paralysis: Surgery or mechanical ventilation?
- Conditions
- halfzijdige middenrifspierverlammingDiaphragm paralylsis
- Registration Number
- NL-OMON56784
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
In order to be eligible to participate in this pilot study, a participant must
meet all of the following criteria:
• >18 years
• diagnosed with a unilateral diaphragm paralysis based on isolated phrenic
nerve injury.
o Unilateral diaphragm paralysis is defined as follows: complaints of dyspnea
and / or orthopnea combined with a drop in VC of more than 15% when change from
upright to supine position and a positive sniff test during fluoroscopy or
ultrasonography. A positive sniff test means that the diaphragm stands still or
even moves in cranial direction (paradoxical movement ) during the sniff
inspiratory maneuver.
• Ability to provide written consent
• Time between diagnosis and treatment should be at least 1 year as a diaphragm
paralysis can recuperate over time due to natural cause
A potential subject who meets any of the following criteria will be excluded
from participation in this pilot study:
• Patients diagnosed with a bilateral diaphragm paralysis unknown cause
• Systemic neurological or neuromuscular disorder like for example Amyotrophic
Lateral Sclerosis
• Hypercapnia during daytime (PaCO2 > 6.0 kPa)
• Radiotherapy of the thorax
• Contra indication for diaphragm surgery.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method