ISRCTN10214981已完成未知

Gut and blood microbiomics for studying the effect of a polyphenol-rich dietary pattern on intestinal permeability in the elderly

European Joint Programming Initiative A Healthy Diet for a Healthy Life” (JPI - HDHL)0 个研究点目标入组 66 人开始时间: 2017年4月28日最近更新: 2024年9月9日

适应症

试验速览

2020 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/32102662 protocol (added 28/02/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33388204/ results (added 04/01/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34534897/ (added 21/09/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34727202/ (added 03/11/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35315592/ (added 23/03/2022) 2020 Interim results article in https://doi.org/10.3390/nu12082458 (added 06/06/2023) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/39182041/ (added 27/08/2024)

•1. Age > 60 years old
•2. Intestinal Permeability evaluated by Zonulin serum level
•3. Adequate nutritional status evaluated with Mini Nutritional Assessment (MNA) score =24
•4. Good cognitive status tested with Mini Mental State Evaluation (MMSE) score =24
•5. Self-sufficiency assessed with validated tests (e.g. Barthel index - activities of daily living, Tinetti balance assessment)

•1. Celiac disease
•2. Severe liver disease with cirrhosis
•3. Severe renal insufficiency (dialysis)
•4. Presence of Chronic Obstructive Pulmonary severe COPD (oxygen therapy for many hours a day) or severe heart failure, i.e. class III or IV NYHA - New York Heart Association
•5. Antibiotic treatment
•6. Malignant tumor that required treatment in the previous 2 years

发起方

European Joint Programming Initiative A Healthy Diet for a Healthy Life” (JPI - HDHL)