A Single Arm Open-label Clinical Study to Investigate the Efficacy and Safety of Ruxolitinib for the Treatment of COVID-19 Pneumonia
Overview
- Phase
- Not Applicable
- Intervention
- Ruxolitinib
- Conditions
- COVID-19
- Sponsor
- University Health Network, Toronto
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- Proportion of patients with COVID-19 pneumonia who become critically ill (defined as requiring mechanical ventilation and/or FiO2 of 60% of more)
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to determine the safety and efficacy of the drug ruxolitinib in people diagnosed with COVID-19 pneumonia by determining the number of people whose conditions worsen (requiring machines to help with breathing or needing supplemental oxygen) while receiving the drug.
This is a sub-study of the U-DEPLOY study: UHN Umbrella Trial Defining Coordinated Approach to Pandemic Trials of COVID-19 and Data Harmonization to Accelerate Discovery. U-DEPLOY helps to facilitate timely conduct of studies across the University Health Network and other centers.
Detailed Description
Multifocal interstitial pneumonia is the most common cause of deterioration in people with COVID-19. This is attributed to a severe reaction where releases too many cytokines (proteins that play an important role in immune responses) which rush into the lungs resulting in lung inflammation and fluid buildup. This can lead to damage to the lungs and leading to breathing problems. Ruxolitinib when given early in the disease, may prevent the overproduction of cytokines which, in turn, may prevent lung damage.
Investigators
Eligibility Criteria
Inclusion Criteria
- •COVID-19 infection diagnosed by nasopharyngeal sample
- •Need for supplemental oxygen to maintain oxygen saturation \> 93%
- •12 years of age or older
Exclusion Criteria
- •Neutrophils \< 1 x 10\^9/L
- •Platelets \< 50 x 10\^9/L
- •Serum total bilirubin \>2.0 x upper limit of normal (ULN)
- •Aspartate aminotransferase (AST), or alanine aminotransferase (ALT) \> 5x ULN
- •Creatinine clearance (CrCl) \< 15 mL/minute
- •Pregnant women
- •Known HBV or HIV infection
- •Signs and symptoms of Varicella Zoster Virus (VZV) infection
- •Patients requiring invasive mechanical ventilation. Patients requiring non-invasive mechanical ventilation (e.g., BiPAP) are eligible.
- •Patients who require supplemental oxygen support prior to COVID-19 infection.
Arms & Interventions
Ruxolitinib to prevent COVID-19 pneumonia
All participants will receive ruxolitinib at at 10 mg, twice a day, for 14 days, followed by 5 mg, twice a day, for 2 days and 5 mg, once daily, for 1 day.
Intervention: Ruxolitinib
Outcomes
Primary Outcomes
Proportion of patients with COVID-19 pneumonia who become critically ill (defined as requiring mechanical ventilation and/or FiO2 of 60% of more)
Time Frame: 6 months
Number of adverse events
Time Frame: 9 months
Secondary Outcomes
- All cause mortality rate(9 months)
- Average duration of hospital stay(9 months)