A Predictive Tool for Predicting Adverse Outcomes in Acute Pulmonary Embolism Patients Using Parameters Obtained by Computed Tomographic Pulmonary Angiography.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Shengjing Hospital
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Adverse outcomes
Study Overview
Brief Summary
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission to predict adverse outcomes within 30 days after admission into hospital.
Detailed Description
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission. The outcomes of interest were defined as the occurrence of adverse outcomes within 30 days after admission into hospital.
Eligible patients were randomized in some ratio into derivation and validation cohorts. The derivation cohort was used to develop and evaluate a multivariable logistic regression model for predicting the outcomes of interest. The discriminatory power was evaluated by comparing the nomogram to the established risk stratification systems. The consistency of the nomogram was evaluated using the validation cohort.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age of ≥ 18 years and a PE diagnosis based on CT pulmonary angiography
Exclusion Criteria
- •pregnancy
- •reception of reperfusion treatment before admission
- •missing data regarding CT parameters, echocardiography, cardiac troponin I (c-Tn I), and N-terminal-pro brain natriuretic peptide (NT-pro BNP) levels.
Arms & Interventions
Acute pulmonary embolism
an age of ≥ 18 years and a PE diagnosis based on CT pulmonary angiography
Outcomes
Primary Outcomes
Adverse outcomes
Time Frame: 7 days and 30 days
The outcomes of interest were defined as the occurrence of adverse outcomes within 30 days after admission. Adverse outcomes were defined as PE-related deaths, the need for mechanical ventilation, the need for cardiopulmonary resuscitation, and the need for life-saving vasopressor and reperfusion treatment.
Secondary Outcomes
No secondary outcomes reported
Investigators
YIZHUO GAO
Principal Investigator
Shengjing Hospital