A Predictive Tool for Predicting Adverse Outcomes in Acute Pulmonary Embolism Patients Using Parameters Obtained by Computed Tomographic Pulmonary Angiography.
概览
- 阶段
- 不适用
- 干预措施
- Acute pulmonary embolism
- 疾病 / 适应症
- Pulmonary Embolism and Thrombosis
- 发起方
- Shengjing Hospital
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Adverse outcomes
- 状态
- 招募中
- 最后更新
- 上个月
概览
简要总结
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission to predict adverse outcomes within 30 days after admission into hospital.
详细描述
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission. The outcomes of interest were defined as the occurrence of adverse outcomes within 30 days after admission into hospital. Eligible patients were randomized in some ratio into derivation and validation cohorts. The derivation cohort was used to develop and evaluate a multivariable logistic regression model for predicting the outcomes of interest. The discriminatory power was evaluated by comparing the nomogram to the established risk stratification systems. The consistency of the nomogram was evaluated using the validation cohort.
研究者
YIZHUO GAO
Principal Investigator
Shengjing Hospital
入排标准
入选标准
- •age of ≥ 18 years and a PE diagnosis based on CT pulmonary angiography
排除标准
- •pregnancy
- •reception of reperfusion treatment before admission
- •missing data regarding CT parameters, echocardiography, cardiac troponin I (c-Tn I), and N-terminal-pro brain natriuretic peptide (NT-pro BNP) levels.
研究组 & 干预措施
Acute pulmonary embolism
an age of ≥ 18 years and a PE diagnosis based on CT pulmonary angiography
结局指标
主要结局
Adverse outcomes
时间窗: 7 days and 30 days
The outcomes of interest were defined as the occurrence of adverse outcomes within 30 days after admission. Adverse outcomes were defined as PE-related deaths, the need for mechanical ventilation, the need for cardiopulmonary resuscitation, and the need for life-saving vasopressor and reperfusion treatment.