Consequences of Eccentric Cycling on Exercise-related Neuromuscular Responses and Biomarkers in Breast Cancer Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer
- Sponsor
- Institut de cancérologie Strasbourg Europe
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Investigate the physiological responses of the eccentric cycling on the knee extensors muscles by changes of neuromuscular parameters
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This is a monocentric, prospective and interventional study aimed to investigating the physiological responses of eccentric compared to concentric cycling realized 1) at the same metabolic demand and 2) at the same mechanical power output. In order to compare the physiological responses between these two cycling modalities, 3 cycling sessions should be performed for each patient where concentric one will serve as reference / comparison to the eccentric one:
- Session (a): eccentric cycling
- Session (b): high intensity concentric cycling realized at the same mechanical power output than eccentric cycling
- Session (c): low intensity concentric cycling realized at the same metabolic demand than eccentric cycling The 3 sessions will be performed for each patient and order will be randomized.
Detailed Description
For each participant, 10 visits will be realized as followed: Visit 1: determination of maximal O2 consumption (VO2max) and first familiarization session to eccentric cycling Visits 2, 3 and 4: second, third and fourth eccentric cycling familiarization sessions Visits 5, 7 and 9: cycling sessions (a), (b) and (c) attributed in a random order Visits 6, 8 and 10: post-24h measurements after cycling sessions
Investigators
Eligibility Criteria
Inclusion Criteria
- •Woman who completed (neo)adjuvant chemotherapy since less than 1 year for a breast cancer
- •Woman under hormonotherapy, or menopausal woman, or woman in amenorrhea
Exclusion Criteria
- •Pregnant and nursing woman
- •psychiatric, musculoskeletal or neurological disorders
- •presenting at least one contraindication to the use of the transcranial magnetic stimulation
- •presenting at least one contraindication to the realisation of the maximum effort test
Outcomes
Primary Outcomes
Investigate the physiological responses of the eccentric cycling on the knee extensors muscles by changes of neuromuscular parameters
Time Frame: 24 hours after pedaling sessions
Measurement of neuromuscular fatigue via change in maximal voluntary isometric contraction of the knee extensors muscles registered via a force sensor.
Secondary Outcomes
- Comparison of muscle pain after eccentric in session (a) and after concentric modalities in session (b) and session (c)(24 hours after pedaling sessions)
- Comparison of central (identified as a decrease in voluntary activation, VA) fatigue after eccentric in session (a) and after concentric modalities in session (b) and session (c)(24 hours after pedaling sessions)
- Comparison of peripheral (identified as a decrease in the quadriceps twitch muscle contractile capacities, Qtw) fatigue after eccentric in session (a) and after concentric modalities in session (b) and session (c)(24 hours after pedaling sessions)
- Comparison of muscle thickness measured via ultrasonography on the vastus lateralis muscle after eccentric modality in pedaling session (a) and after concentric modalities in pedaling sessions (b) and (c)(24 hours after pedaling sessions)
- Comparison of muscle fibers pennation angle measured via ultrasonography on the vastus lateralis muscle after eccentric modality in pedaling session (a) and after concentric modalities in pedaling sessions (b) and (c)(24 hours after pedaling sessions)
- Comparison of muscle fibers fascile length measured via ultrasonography on the vastus lateralis muscle after eccentric modality in pedaling session (a) and after concentric modalities in pedaling sessions (b) and (c)(24 hours after pedaling sessions)
- Comparison of muscle echogenecity measured via ultrasonography on the vastus lateralis muscle after eccentric modality in pedaling session (a) and after concentric modalities in pedaling sessions (b) and (c)(24 hours after pedaling sessions)
- Comparison of blood markers in session (a) and after concentric modalities in session (b) and session (c)(24 hours after pedaling sessions)