To check the amount of bone growth by using artificial bone material with and without Hyaluronic acid gel in patients with severe gum disease.

Phase 1

Active, not recruiting

Conditions: Chronic Periodontitis

Registration Number: CTRI/2017/11/010591

Lead Sponsor: Eeshita Bhowmik

Brief Summary: Periodontitis is an inflammatorydisease of the supporting tissues of the teeth caused by specificmicroorganisms or groups of specific microorganisms, resulting in progressivedestruction of the periodontal ligament and alveolar bone with pocket formation,recession or both. 1

Periodontal therapy aims primarily atthe arrest of progression of disease, along with formation of new bone,cementum and periodontal ligament (PDL). 2

Various types of bone grafts have beenused along with conventional surgical procedures for regeneration of bone andPDL.3 Hydroxyapatite, having a biomimetic property of replicatingthe native mineral content of bone tissue, is most commonly used. It is osteophilicand osteoconductive. Osteoconductive materials neither inhibit nor induce boneformation. They only act as a scaffold for bone formation.4

Hyaluronan or Hyaluronic acid, animportant component of extra cellular matrix, on the other hand, has astimulatory effect on osteoblasts. Thusit imparts osteogenic and osteoconductive properties to bone graft, when addedto it. It also acts as a connective tissuescaffold allowing cell growth and regeneration of bone.5

Hence an attempt is being made in thisstudy to combine the properties of both the above materials for regeneration ofbone.

As per our knowledge there are verysparse studies evaluating the efficacy of hyaluronan and bone graft together.Thus, in this study, an attempt is made to evaluate the regenerative propertyof hyaluronan in combination with Nano-hydroxyapatite bone graft in comparisonwith Nano-hydroxyapatite bone graft alone, in the surgical management ofinfrabony defects, in patients with chronic periodontitis.

Detailed Description: Not available

Recruitment & Eligibility

Status: Closed to Recruitment of Participants

Sex: All

Target Recruitment: 10

Inclusion Criteria

Systemically healthy male and female patients in the age range of 30-55 years having chronic generalised periodontitis.
Patients with contralateral intrabony pockets measuring more than or equal to 6mm.
Patients with radiographic evidence of bilateral vertical/angular defects.
Consenting patients who are cooperative and ready for regular follow up.

Exclusion Criteria

Patients on antibiotic therapy in the previous six months.
Patients who have undergone any periodontal therapy in past 6 months.
Pregnant /lactating women.
Patients who are medically compromised or under therapeutic regimen that may alter the probability of soft tissue and bone healing.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
efficacy of Hyaluronan-Nano hydroxyapatite composite graft in comparison with Nano hydroxyapatite graft alone, in the treatment of infrabony defects.	12 month period (3,6,9,12 month)

Secondary Outcome Measures

Name	Time	Method
to evaluate Clinical Parameters and Bone fill	3,6,9,12 months

Trial Locations

Locations (1): JSS Dental College and Hospital
🇮🇳
Mysore, KARNATAKA, India
JSS Dental College and Hospital
🇮🇳Mysore, KARNATAKA, India
Eeshita Bhowmik
Principal investigator
7829916764
dr.eeshita@gmail.com