A study to compare function and phenotype of bone marrow and circulating immune cells of healthy control subjects to vascular patients

Completed

• Conditions: heart attack; myocardial infarction; 10011082; 10003216

• Registration Number: NL-OMON46975
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Age: >34 years old (mean age 57 years)
- Gender: subjects of either gender (85% male)
- BMI between 18 and 33 kg/m2

Exclusion Criteria

- Clinically evidence or at increased risk for cardiovascular disease or diabetes
- Clinically evidence for chronic inflammation
- Use of any cardiovascular medication, including but not limited to lipid-lowering therapy, antihypertensive drugs, antidiabetic drugs, platelet aggregation inhibitors and anticoagulants
- Any other known systemic disorder such as hepatic, renal, hematologic, and malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is GM-CFU of bone marrow HSPCs (=function)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary study parameter is flow cytometry of HSPCs (=phenotype) from bone<br /><br>marrow and blood </p><br>