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临床试验/NCT01272700
NCT01272700已完成不适用

The Effect of Pressure Controlled Ventilation on the Pulmonary Mechanics in Prone Position Using the Wilson Frame: A Comparison With Volume Controlled Ventilation

Yonsei University2 个研究点 分布在 2 个国家目标入组 40 人开始时间: 2010年8月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
40
试验地点
2
主要终点
peak airway pressure

研究概览

简要总结

Prone position in spinal surgery can increase airway pressure and decrease dynamic lung compliance by a frame used for postural stabilization. Also, it can increase hemodynamic instability such as reduced blood pressure by aggravating cardiac index.

Former study shows pressure controlled ventilation on the pulmonary mechanics can improve alveolar use and oxygenation than volume controlled ventilation. The latter one means controlling a patient's breathing completely through tidal volume and set breathing rate. This could be useful for the patients not possible to breath by themselves because it guarantees the perfect breathing.

The pressure controlled ventilation is used when there is a possibility to change a patient's environment. The pressure will be maintained steadily, but volume and flux will be changed. That means through the pressure already set, the whole breathing will be maintained from the beginning to end. If a patient's resistance is increased, the volume will be decreased even though the way of blood pressure control is same. However, the tidal volume per minute can be controlled somewhat and barotrauma can be decreased by controlling respiratory rate. Through this study, we are expecting the pressure controlled ventilation in prone position can improve lung mechanics and oxygenation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Double (Participant, Investigator)

入排标准

年龄范围
20 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • scheduled for lumbar spine surgery under general anaesthesia

排除标准

  • Patients with coronary artery occlusive disease
  • morbid obesity (body mass index ≥ 30 kg/m2)
  • cerebrovascular disease and major obstructive or restrictive pulmonary disease

研究组 & 干预措施

PCV

Experimental

Peak airway pressure were set to deliver a tidal volume of 10 ml/kg of ideal body weight

干预措施: volume control (Procedure)

VCV

Active Comparator

After anesthetic induction, anesthesia maching were set to deliver a tidal volume of 10 ml/kg of ideal body weight

干预措施: pressure control (Procedure)

结局指标

主要结局

peak airway pressure

时间窗: 30 minutes after prone position

Record peak airway pressure on anesthesia mechanical ventilator after anesthesia induction and 30 minutes after prone positioning.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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