Comparative Study of Metformin Versus Doxycycline in Treatment of Moderate to Severe Adult Acne Vulgaris Patients: Multicentre, Randomized, Double-blind Trial.
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Global Acne Grading System (GAGS) Score
研究概览
简要总结
The goal of this clinical trial is to compare the effect of doxycycline and metformin in treatment of acne vulgaris patients. The main question is aimed to answer is whether metformin is more effective than doxycycline in treatment of acne vulgaris patient or not.
Patients will be asked to take doxycycline along with tropical treatment in one group and metformin along with tropical treatment in another group.
Researcher will compare the clinical improvement in two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed moderate and severe AV patients diagnosed by a dermatologist
排除标准
- •Patients receiving topical retinoids within last two months
- •Pregnancy and lactation
- •History of corticosteroids intake
- •Suffering from malignancy or any cosmetic induced acne
研究组 & 干预措施
Group A
Metformin 500 mg twice daily along with topical retinoids for 12 weeks
干预措施: Metformin and doxycycline (Drug)
Group B
Doxycycline 100 mg twice daily along with topical retinoids for 12 weeks
干预措施: Metformin and doxycycline (Drug)
结局指标
主要结局
Global Acne Grading System (GAGS) Score
时间窗: 12 weeks
Acne Vulgaris Severity assesment by GAGS score
次要结局
未报告次要终点
研究者
Dr. Muhammad Marnush
Principal Investigator
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh