The effect of microbiome manipulation through diet and Fecal Microbial Transplant (FMT) in inducing and maintaining remission in patients with mild to moderate ulcerative colitis: open label randomized controlled trial

All India Institute of Medical Sciences0 个研究点目标入组 66 人开始时间: 2022年3月16日最近更新: 2022年8月29日

适应症

试验速览

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35973787/ (added 17/08/2022)

•1. Age between 18 – 65 years
•2. Patients with mild to moderate ulcerative colitis as assessed by simple clinical colitis activity index (SCCAI, 3 – 9) of any disease extent along with active disease on endoscopy (ulcerative colitis index of severity, UCEIS >1)
•3. Patients on stable doses of 5-ASA (5-amino salicylic acid) for past 4 weeks
•4. Patients on stable doses of azathioprine/6-mercaptopurine for past 3 months
•5. Patients who received biologics 6 months ago
•6. Patients on stable doses of topical therapy for past 2 weeks
•7. Patients on oral steroids (equivalent dose of prednisolone <20 mg/day)
•8. Patients giving consent for FMT
•9. Patients who agree to adhere to the diet schedule

•1. Patients with severe disease activity
•2. Patients who have received topical 5-ASA or topical steroids in the past 2 weeks
•3. Patients with H/O of antibiotic or probiotic exposure in the past 4 weeks
•4. Patients requiring hospitalization
•5. Patients with H/O bowel surgery
•6. Patients with concomitant GI infection
•7. Pregnancy
•8. Patients with other comorbid illnesses

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