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临床试验/NCT06686095
NCT06686095已完成不适用

Comparison of Analgesic Effect of Adductor Canal Block, IPACK, and Genicular Nerve Block Following Total Knee Arthroplasty Under Spinal Anesthesia

Hitit University2 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2022年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
90
试验地点
2
主要终点
Postoperative Pain Examination with Numeric Rating Scale

研究概览

简要总结

Patients with total knee arthroplasty (TKA) experience severe postoperative pain. This reduces patient satisfaction, delays mobility, and prolongs hospital stay. Peripheral nerve blocks, which are part of multimodal analgesia, are widely used in postoperative pain management. In this study, the effects of adductor canal block (ACB), popliteal artery and knee capsule infiltration block (IPACK), and genicular nerve block (GSB) on postoperative VAS score, opioid consumption, and mobility were investigated.

详细描述

Total knee arthroplasty (TKA) is a surgical procedure performed on patients with severe pain and severely limited range of motion in the knee joint due to knee osteoarthritis, when traditional conservative treatments have failed. Fifty-eight percent of patients who undergo TKA experience moderate or severe pain in the postoperative period. Inadequate pain control leads to complications such as venous thrombosis, coronary ischemia, myocardial infarction, and pneumonia, and increases morbidity. In addition, failure to control postoperative pain negatively affects physical therapy procedures. This situation prolongs the rehabilitation and hospital stay of patients, thus increasing care costs. Therefore, it is of great importance to reduce the patient's pain after TKA.

Femoral nerve block (FNB) has traditionally been a critical component of multimodal analgesia in TKA due to its high analgesic efficacy. However, FNB limits physical therapy by causing motor limitations in the quadriceps muscle. This situation causes delays in ambulation and discharge. Due to the difficulties in rehabilitation observed in patients undergoing FNB due to quadriceps muscle weakness, different techniques were sought and the Adductor canal block (ACB) emerged. AKB is a sensory block that blocks the saphenous nerve, a sensory nerve that courses in the adductor canal in the thigh, thus preserving motor function. It is an alternative block to FNB by providing adequate analgesia to the anterior compartment of the knee.

Genicular nerves include branches of the femoral, common peroneal, saphenous, tibial and obturator nerves that innervate the knee capsule. It is known that the superolateral, superomedial and inferomedial branches of the genicular nerve are close to the periosteum of the tibia and femur and play a role in sensory innervation of the anterior part of the knee joint. Genicular nerve block (GNB) is used in chronic osteoarthritis pain and has been used in recent years to relieve postoperative pain in TKA.

Infiltration between Popliteal Artery and Capsule of the Knee (IPACK block) is performed by infiltrating local anesthetic (LA) between the popliteal artery and the knee capsule under USG guidance. The sciatic nerve has an important function in the motor and sensory innervation of the posterior leg. In the IPACK block application, the LA spreads along the popliteal fossa and proximal sciatic nerve involvement does not occur. Thus, the sensory nerve network innervating the posterior part of the knee is blocked. Since IPACK block provides only sensory block without causing motor block, it is a new method recommended for analgesia in knee surgery as an alternative to sciatic nerve block, which causes motor block.

Method:

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • ASA I-II-III
  • BMI < 40
  • 18-80 years old

排除标准

  • <18 years, >80 years
  • Will undergo revision TKA surgery
  • Will undergo bilateral TKA surgery
  • BMI > 40
  • Patients who used high dose opioid medication within 3 days before surgery
  • those with widespread chronic pain, diabetes mellitus, a history of neuromuscular disease, hepatic and renal failure
  • who underwent general anesthesia during the intraoperative period

结局指标

主要结局

Postoperative Pain Examination with Numeric Rating Scale

时间窗: 48 hours

Determination of patients' post-operative pain level. The Numeric Rating Scale (NRS), a method that converts the patient's pain perception into a numerical form, will be used to assess postoperative pain. NRS has a numerical scale ranging from 0 to 10. The patient will rate the intensity of pain on a scale from 0, indicating no pain, to 10, representing the worst imaginable pain (NRS 0=no pain, 4=mild to moderate pain, 6-8=severe pain, and \>8=intolerable pain).

次要结局

未报告次要终点

研究者

发起方
Hitit University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Selcuk KAYIR

Associate Professor

Hitit University

研究点 (2)

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