Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 61
- Locations
- 2
- Primary Endpoint
- morphological of tubal cilia
Study Overview
Brief Summary
Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women
Detailed Description
Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP.
Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with scheduled salpingectomy (Ectopic pregnancy, hysterectomy for prolapsus, adenomyosis or myomectomy)
- •Major patients ( >18 years)
Exclusion Criteria
- •Patient not willing to participate in the study
Arms & Interventions
Salpingectomy for Extra-Uterine Pregnancy
patients with salpingectomy for Ectopic Pregnancy
Intervention: salpingectomy (Procedure)
hysterectomies
patients with hysterectomy for prolapsus, adenomyosis or myomectomy
Intervention: hysterectomy (Procedure)
Outcomes
Primary Outcomes
morphological of tubal cilia
Time Frame: through study completion, an average of 6 week after surgery
Molecular compositor of tubal ciliar by immunofluorescence study of 14 proteins in vivo and in vitro (tissue cells from patient fallopian tubes)
Molecular difference in tubal cilia between patients with or without GEU salpingectomy
Time Frame: through study completion, an average of 6 week after surgery
compares molecular compositor of tubal ciliar by immunofluorecence study of 14 proteins in vivo and in vitro between patients with or without GEU salpingectomy
molecular tubal cilia
Time Frame: through study completion, an average of 6 week after surgery
Ultrastructure morphology of tubal cell cilia by electron microscopy
functional composition of tubal cell by video microscopy
Time Frame: through study completion, an average of 6 week after surgery
amplitude of moment by video microscopy
Secondary Outcomes
No secondary outcomes reported