Diagnostic and Prognostic Value of Combination Biomarkers in the Critically Ill Patient With Sepsis.

• Conditions: Diagnostic and Predictive Value

• Registration Number: NCT01687010
• Lead Sponsor: Jianfeng Xie

Brief Summary

Sepsis is a common cause for morbidity and mortality in critically ill patients. With the development of medical skills, the mortality is still remain very high. Inappropriateness of initial antibiotic treatment is an important risk factor for mortality and effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock. However, the early treatment based on early diagnosis.But it is very difficult to diagnosis because of lack of specific clinic symptom and sign.When severe sepsis occur, biomarker could be helpful to diagnosis. Unfortunately, the diagnostic value of single biomarker is limited. Therefore, combine several biomarkers could enhance the diagnostic value.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Status Verified: 2012-08
• Study First Submitted: 2012-09-13
• Study First Submitted QC: 2012-09-17
• Last Update Submitted: 2012-09-17
• Study First Posted: 2012-09-18
• Last Update Posted: 2012-09-18
• Study Completion: 2012-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Critically ill patients admitted into ICU

Exclusion Criteria

• Age younger than 18 years
• Refuse to participate in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Critical Care Medicine Nanjing Zhong-da Hospital Southeast University School of Medicine; 🇨🇳 Nanjing, Jiangsu, China