Developing diagnostic criteria for the differentiation between large vessel vasculitis and atherosclerosis using 18FDG-PET/CT

Completed

• Conditions: atherosclerose (bloedvataandoeningen); blood vessel calcification; blood vessel inflammation; 10047066

• Registration Number: NL-OMON42061
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Group I:
Patients with biopsy-proven giant cell arteritis with any type/degree of large-artery 18-FDG-uptake in the absence of clues pointing to severe atherosclerosis (history of cardiovascular disease or a >2-fold increased age-adjusted CVD risk. Patient scans will be retrieved from our database.;Group II:
Patients with severe atherosclerosis affecting at least the thoracic and/or abdominal- iliacal aorta and any type/degree of large-artery 18-FDG uptake. Patients >50 years of age with manifest atherosclerotic disease will be selected from the vascular surgery outpatient clinic.

Exclusion Criteria

Group I:
Use of immunosuppressive drugs
Known cancer
Reluctance or inability to provide informed consent;Exclusion criteria for group II:
ESR >30 mmHg and/or CRP >10 mg/l
Myalgia in shoulder/pelvic regions (suggestive of PMR)
History of vasculitis or other type of systemic auto-immune disease
Use of immunosuppressive drugs
Reluctance or inability to provide informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We anticipate that criteria relating to 18-FDG uptake distribution and<br /><br>intensity, and presence of calcium deposits on low-dose CT, will differentiate<br /><br>between vasculitis and atherosclerosis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>