Bendamustine and Rituximab for the treatment of Splenic Marginal Zone Lymphoma. The IELSG-36 phase II prospective study.

Phase 1

• Conditions: Splenic Marginal Zone Lymphoma; MedDRA version: 14.1Level: PTClassification code 10062113Term: Splenic marginal zone lymphomaSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps); Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2011-000880-28-IT
• Lead Sponsor: INTERNATIONAL EXTRANODAL LYMPHOMA STUDY GROUP (IELSG)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-10-25
• Study Completion: 2020-12-30
• Last Update Posted: 4 April 2022

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

Inclusion criteria •Initial diagnosis of CD20+ Splenic Marginal Zone Lymphoma morphology confirmed by histology, cytology, immunophenotype (chromosomal abnormalities by quantitative multiplex PCR of short fluorescent fragments (QMPSF) is optional) according to WHO 2008 classification of Lymphoma criteria or according to the recommendation of the Splenic Lymphoma Group (Matutes et al. Leukemia 2008) for non splenectomized patient. 1.If patients not splenectomised: diagnosis on bone marrow biopsy (histology and immunohystochemistry), and blood (cytology, immunophenotype), chromosomal abnormalities by QMPSF optional. 2.If patients splenectomised diagnosis on spleen, bone marrow biopsy (histology and immunohistochemistry), and blood (cytology, immunophenotype) chromosomal abnormalities by QMPSF optional. •No previous treatment with immunotherapy or chemotherapy or radiotherapy unless pretreatment by monocorticotherapy. •Patients requiring a treatment with at least one of the following situation: 1)Symptomatic SMZL in not splenectomized patients a)Bulky (arbitrarily defined as =6 cm below left costal margin) or progressive or painful splenomegaly, without enlarged lymphoadenopathy, with or without cytopenia, not eligible for splenectomy or not willing splenectomy b)One of the following symptomatic/progressive cytopenias: Hb <10 g/dL, or Plat <80.000/mm3, or ANC <1.000/mm3, whatever the reason (autoimmune or hypersplenism or bone marrow infiltration) not eligible for splenectomy or not willing splenectomy c)SMZL with enlarged lymphoadenopathy or involvement of extranodal sites with or without cytopenia 2)Symptomatic disease in SMZL splenectomised patients with rapidly raising lymphocyte counts, development of lympadenopaty or involvement of extranodal sites. 3)SMZL with concomitant hepatitis C infection who have not responded or are relapsed after Interferon and/or Ribavirin. •Clinically and/or radiologically confirmed measurable disease before treatment start. •Aged = 18 at time of initial diagnosis and = 80 yo. •Eastern Cooperative Oncology Group [ECOG] performance status 0-2 (Appendix C). •Minimum life expectancy of >6 months. •Voluntary signed informed consent before performance of any study related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care. •The following laboratory values at screening: 1.Absolute neutrophil count (ANC) ?1.000/mm3 and Platelets ?100.000/mm3, unless these abnormalities are related to bone marrow infiltration or to hypersplenism. 2.Aspartate transaminase (AST) ?2 x ULN; Alanine transaminase (ALT) ?2 x ULN; total bilirubin ?1.5 x ULN. 3.Creatinine clearance = 10 ml/min (as calculated by the Cockcroft-Gault formula - Appendix I).
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 30
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 35

Exclusion Criteria

Exclusion criteria •Any type of lymphoma other than SMZL. •Patients with proven biopsy of histological transformation. •Contraindication to any drug contained in the chemotherapy regimen. •Myocardial infarction during last 3 months or unstable coronary disease or uncontrolled chronic symptomatic congestive heart insufficiency NYHA III – IV (Appendix H). •Uncontrolled hypertension. •Uncontrolled diabetes mellitus as defined by the investigator. •Active systemic infection requiring treatment. •HIV positive serology. •Active hepatitis B virus infection (presence of antigen HBS+; in case of presence of antibody anti HBC+ and anti HBS+, controls should be organized according to guidelines of AASLD and l’EASL). •Active and previously untreated HCV infection •Prior history of malignancies other than lymphoma within 3 years (except for complete resection of basal cell carcinoma, squamous cell carcinoma of the skin, or in situ malignancy). Patients previously diagnosed with prostate cancer are eligible if (1) their disease was T1-T2a, N0, M0, with a Gleason score ?7, and a prostate specific antigen (PSA) ?10 ng/mL prior to initial therapy, (2) they had definitive curative therapy (ie, prostatectomy or radiotherapy) ?2 years before Day 1 of Cycle 1, and (3) at a minimum 2 years following therapy they had no clinical evidence of prostate cancer, and their PSA was undetectable if they underwent prostatectomy or <1 ng/mL if they did not undergo prostatectomy. •A positive Coombs test without haemolysis or an autoimmune hemolytic anemia is not an exclusion criterion. •Severe chronic obstructive pulmonary disease with hypoxemia. •Medical condition requiring long-term use (>1 months) of systemic corticosteroids. •Serious medical or psychiatric illness likely to interfere with participation in this clinical study. •Prior participation in another study with experimental drug during the last 4 months. •Pregnant or currently breast-feeding woman.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified