TO STUDY HOW SGLT2 INHIBITOR DRUGS IMPROVE HEARTS PUMPING CAPACITY IN NON DIABETIC HEART FAILURE PATIENTS

Not Applicable

• Conditions: Health Condition 1: I420- Dilated cardiomyopathy

• Registration Number: CTRI/2023/02/050151
• Lead Sponsor: Dr Nagpal Raghav Radhakrishan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 March 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

LVEF equal to or less than 45%

More than 3 months from ACS event

Ischemic Cardiomyopathy patients who have undergone complete revascularization in the form of percutaneous coronary intervention or surgery more than 3 months prior to inclusion in the study

Creatinine clearance of less than equal to 30 ml per min per m2

Patients on optimal heart failure therapy, beta blockers ARB ACE inhibitors aldosterone antagonists and or diuretics if tolerated

Exclusion Criteria

1) Diabetes Mellitus

2) Recent ACS, <3 months

3) Ischemic cardiomyopathy patients who have not undergone complete revascularization

4) Coronary Revascularization ( percutaneous coronary revascularization or coronary artery bypass grafting) or valvular repair/replacement within 3 months prior to enrolment

5)severe infection

6) serious liver or renal functional failure eGFR < 30 ml/min/m2

7) alcohol dependency or use of illicit drugs

8) pregnant or breastfeeding, possibly pregnant or planning to become pregnant in the study period (female patients only)

9) urinary tract or genital infection

10) history of hypersensitivity to the study drugs

11) severe ketosis, diabetic coma or precoma

12) ongoing or past history of pancreatitis

13) heart failure due to restrictive cardiomyopathy, active myocarditis, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease

14) symptomatic bradycardia or second or third degree heart block without a pacemaker

Study & Design

• Study Type: Observational
• Study Design: Not specified