?Effects of Atomoxetine and Trazodone combination in obstructive sleep apnea
- Conditions
- obstructive sleep apnea.Obstructive sleep apnea (adult) (pediatric)G47.33
- Registration Number
- IRCT20220607055095N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 18
Definite diagnosis of obstructive sleep apnea in medical history with AHI>15 in polysomnography
lack of compliance treatment with CPAP or BIPAP
either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert
commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes)
any underlying cardiac disease, such as arrhythmia that is seen on the ECG
History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Hypersensitivity to lidocaine, atomoxetine or trazodone, substances used in placebo
Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles
Inability to sleep in supine position
Pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Apnea-hypopnea index. Timepoint: medication Night. Method of measurement: Polysomnography.
- Secondary Outcome Measures
Name Time Method Safety. Timepoint: The morning after taking the drug. Method of measurement: asking the patient.