IRCT20220607055095N1
Completed
Phase 2
Evaluating the effects of the Atomoxetine and Trazodone combination on the number of apneas and apnea-hypopnea sleep index in obstructive sleep apnea patients referred to the sleep clinic of Imam Khomeini hospital.
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- obstructive sleep apnea.
- Sponsor
- Tehran University of Medical Sciences
- Enrollment
- 18
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Definite diagnosis of obstructive sleep apnea in medical history with AHI\>15 in polysomnography
- •lack of compliance treatment with CPAP or BIPAP
- •either the patient is unwilling to have surgery or they are not candidates for surgery in the opinion of the expert
Exclusion Criteria
- •commodities' existence (excluding controlled blood pressure, hyperlipidemia and diabetes)
- •any underlying cardiac disease, such as arrhythmia that is seen on the ECG
- •History of seizures, Panic disorder, Hyperventilation syndrome, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
- •Hypersensitivity to lidocaine, atomoxetine or trazodone, substances used in placebo
- •Taking any medication that leads to changes in the physiology of breathing, sleep / wake and muscles Taking any medication that leads to changes in the physiology of breathing, sleeping / waking and muscles
- •Inability to sleep in supine position
Outcomes
Primary Outcomes
Not specified
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