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Clinical Trials/NCT04514055
NCT04514055CompletedNot Applicable

Evaluation of a De-epithelialized Free Gingival Connective Tissue Graft Wall Technique in Management of Cairo's RT2 and RT3 With Intra-bony Defects: A Case Series

Cairo University2 sites in 1 country10 target enrollmentStarted: October 1, 2020Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
10
Locations
2
Primary Endpoint
Gingival recession depth

Study Overview

Brief Summary

Recession presents a day to day challenge due to the high esthetic demand of the patients. The prevalence, extent, and severity of recession associated with intra-bony defects due to periodontitis increases with age rendering the success of the root coverage procedures questionable due to loss of interdental papillary support. .

Therefore, connective tissue graft wall technique in cases of Cairo's RT2 and RT3 gingival recession associated with intra bony defects seems promising with regard to recession depth reduction and radiographic bone fill.

Detailed Description

Recession is usually treated by an array of mucogingival surgical techniques. The choice of the procedure depends on the morphology of the recession defect. Full root coverage in RT2 and RT3 gingival recession defects cannot always be predictably achieved due to the presence of bone loss. Improvement is further complicated when these recessions are associated with intra-bony defects as mucogingival surgical techniques are not designed to treat intra-bony defects. The preferred surgical modality for treatment of intrabony defects is guided tissue regeneration. However when considering recession defects, the amount of root coverage achieved by GTR may be limited with less results achieved.

Most of the root coverage procedures have proven to be successful, however, when recession is associated with intrabony defect especially in cases of low height and thickness of keratinized tissue and GTR is performed, the treatment results were unpredictable and it was found that the recession might increase post-surgically, so the procedure might offer a limited benefit.

Therefore, the technique introduced by Zucchelli et al. in 2014 in cases of RT2 and RT3 gingival recession associated with intra bony defects seems promising with regard to recession depth reduction and radiographic bone fill. A simplified papilla preservation technique was performed on the defect site, a de-epithelialized free gingival graft was used to treat the gingival recession present and intrabony defects because it acted as a membrane, creating a buccal wall to the intra-bony defect from one side and on the palatal aspect since no flap elevation was done. The palatal connective tissue acted as a palatal wall preventing gingival epithelium and connective tissue from contacting the space created allowing both improved root coverage and bone fill. He reported interproximal probing depth reduction, clinical attachment gain, improvement in the papilla covering the intrabony defect regarding the gingival thickness and root coverage and complete bone fill was shown radiographically in 1 year.

This technique needs more investigations, but it seems encouraging to improve regenerative and esthetic parameters in the treatment of deep infrabony defects, in one surgical session.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
20 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Teeth with buccal RT2 and RT3 recession associated with an intra-bony defect on single rooted teeth.
  • Single and multiple recessions.
  • Full mouth plaque score (FMPS )<20% at baseline.
  • Full mouth bleeding score (FMBS )<10% at baseline.
  • Systemically healthy.
  • Cooperative patients.

Exclusion Criteria

  • Pregnancy and lactation.
  • Stage 4 Grade C periodontitis.

Outcomes

Primary Outcomes

Gingival recession depth

Time Frame: Changes at 3 and 6 months post-operative

Measured from the cementoenamel junction to the gingival margin using a William's graduated periodontal probe. The probe will be inserted into the sulcus gently parallel to the long axis of the tooth.

Secondary Outcomes

  • Width of the Keratinized Tissue(At 3 and 6 months post-operative)
  • Probing Depth(Changes at 3 and 6 months post-operative)
  • Radiographic bone fill(At 6 months post-operative)
  • Percentage of Root Coverage(Changes at 3 and 6 months post-operative)
  • Gingival Recession Width(Changes at 3 and 6 months post-operative)
  • Post-Operative Pain(At 7 and 14 days post-operative)
  • Bleeding on Probing(At 6 months post-operative)
  • Plaque Index(At 6 months post-operative)
  • Gingival Thickness(Changes at 3 and 6 months post-operative)
  • Clinical Attachment Level(At 3 and 6 months post-operative)
  • Post-Operative patient's Satisfaction(At 6 months post-operative)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Mariam Galal Bendary

principal investigator

Cairo University

Study Sites (2)

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