An interventional study to evaluate the effect of syrup mutra sangrahaneeya mahakashaya in participients of childhood nephrotic syndrome.

Phase 2

• Conditions: Health Condition 1: N049- Nephrotic syndrome with unspecified morphologic changes

• Registration Number: CTRI/2024/07/069889
• Lead Sponsor: O SPONSER

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Diagnosed cases of Minimal Change steroid dependent Nephrotic Syndrome with less than three relapses so far.

2.Diagnosed cases of Minimal Change Nephrotic Syndrome with less than nephrotic range of proteinurea (not more than 3gm/24 hr protein loss)

3.Diagnosed cases of Minimal Change Nephrotic Syndrome without any documented adverse effects of steroid therapy.

4.Diagnosed cases of Minimal Change Nephrotic Syndrome with chronicity of less than 1 year.

Exclusion Criteria

1.Child with more than three episodes of recurrences requiring higher doses of steroid and with chronicity of more than one year and more than three relapses so far.

2.Children with gross Congenital Anomalies, urogenital anomalies

3.Children with Genetic Nephrotic Syndrome and involvement of kidney parenchyma

4.Children with Secondary Glomerulonephritis (eg. Post infectious Glomerulonephritis, SLE, Diabetic neuropathy, Henoch-Schonlein Syndrome)

5.Children of Nephrotic Syndrome with end stage disease.

6.Children receiving immune-suppressant other than steroid like cytotoxic drugs etc. with indication of renal biopsy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Proteinurea in children with Minimal Change Nephrotic SyndromeTimepoint: at baseline,15th day, 30th day, 45th day, 60th day,75th dayand 90th day

Secondary Outcome Measures

Name	Time	Method
•Change in biochemical parameters e.g., serum protein, serum cholesterol, serum creatinine <br/ ><br>•Change in quality of life & general condition of children. <br/ ><br>Timepoint: 90th day