Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients
Not Applicable
Completed
- Conditions
- Primary Open-angle Glaucoma
- Interventions
- Registration Number
- NCT02077231
- Lead Sponsor
- Xiaodong Zhou
- Brief Summary
Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year.
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Exclusion Criteria
- any systemic diseases which may cause ocular damage;
- previous ocular trauma or surgery;
- contact lens wear history in previous 6 months;
- application of any artificial tears 3 months ago;
- allergic to any of the drugs we used during examination.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description carbomer eye gel carbomer eye gel 0.2% Carbomer 940; Bausch \& Lomb, Aschheim, Germany vitamin A palmitate eye gel Vitamin A 0.1% vitamin A palmitate; Sinqi, Shenyang, China
- Primary Outcome Measures
Name Time Method change of the density of conjunctival goblet cells change from Baseline in goblet cell density at 6 months
- Secondary Outcome Measures
Name Time Method tear film parameters changes in patients change from baseline in TBUT and Schirmer test at 6 months changes of ocular irritation in patients change from baseline in OSDI scores at 6 months