Effect of Early Mechanical Ventilation to Severe Acute Pancreatitis
试验速览
- 阶段
- 不适用
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Mechanical Ventilation Time
研究概览
简要总结
Acute lung injury (ALI) and acute respiratory distress syndrome(ARDS) represent the most common and earliest organ dysfunction in acute pancreatitis, presenting as dyspnea and intractable hypoxemia, with secondary bilateral pulmonary infiltrates on radiograph. And mechanical ventilation (MV) is the essential intervention to improve oxygenation. When to initiate MV remains uncertain. In this study, we aim to compare the effect of early MV and conventional MV, and we hypothesize that early MV may be a better treatment option.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of pancreatitis:typical pain, increase in serum lipase or amylase, onset of abdominal pain within 72h before admission
- •The diagnosis criteria of Severe Acute Pancreatitis is according to Atlanta criteria revisited in 2012
- •the diagnosis of ARDS meets the criteria of Berlin definition
排除标准
- •chronic respiratory disease as chronic obstructive pulmonary disease (COPD), asthma
- •organic cardiopathy
- •pregnancy
研究组 & 干预措施
early mechanical ventilation
Fulfillment of three or more criteria below:
respiratory rate > 28 per minute serum lactate > 3 mmol/L PaO2/FiO2 Index <300 mmHg SvO2 < 65% lung infiltration or atelectasis, pleural exudation
Abbreivation: PaO2, arterial partial pressure of oxygen; FiO2, fraction of inspired oxygen; SvO2, venous oxygen saturation
干预措施: early mechanical Ventilation (Other)
conventional mechanical ventilation
other group who don't start early mechanical ventilation and fulfillment four criteria below: respiratory rate > 28 bpm dyspnea PaO2/FiO2 Index <200 mmHg Chest X-ray: lung infiltration exclude chronic heart failure and pulmonary disease
干预措施: Conventional Mechanical Ventilation (Other)
结局指标
主要结局
Mechanical Ventilation Time
时间窗: 28 days
次要结局
- the incidence of ventilation associated pneumonia(28 days)