Pain relief after laparoscopic procedure

Phase 1

Recruiting

Brief Summary: The aim of the presentstudy is to compare and evaluate the effects of intraperitoneal instillation of0.25% levobupivacaine plus dexmedetomidine versus 0.25% ropivacaine plusdexmedetomidine for postoperative analgesia in patients undergoing laparoscopiccholecystectomy. The aim will be accomplished by carrying out a study on 90patients randomly divided into 3 groups of 30 each in the age group of 18-65years, of either sex, of ASA grade I, II and III selected for laparoscopiccholecystectomy after proper preanaesthetic check up. Postoperative analgesiawill be achieved in group L by using 40 ml of 0.25% levobupivacaine plusdexmedetomidine @ 1Âµgm per Kg Body weight and in group R by using 40 ml of0.25% ropivacaine plus dexmedetomidine @ 1Âµgm per Kg Body weight and Group Cwill be given 40 ml Normal Saline. Thethree groups will be compared with respect to haemodynamic changes, onset andregression of analgesia, requirement of rescue analgesia, side effects andcomplications with the help of scale discussed in plan. The observation will berecorded and the results will be statistically analysed.

Recruitment & Eligibility

Inclusion Criteria

1. All patients of 18.
65 years of either sex 2. All ASA grade I and II admitted in the Surgery department. 3. Patients posted for laparoscopic cholecystectomy surgery under general anaesthesia.

Exclusion Criteria

Pregnant and lactating women Patients with morbid obesity i.e. BMI of 35 Kg/m2.
Patients on psychotropic or adrenergic drugs Refusal by patient to enlist in study â—Patients with chronic pain syndrome.
â—History of previous abdominal surgery.
Allergy to study drug.

Primary Outcome Measures

Name	Time	Method
1.To study the post-operative analgesic effect of 0.25% levobupivacaine plus dexmedetomidine with 0.25% ropivacaine plus dexmedetomidine with Normal Saline (Control Group) following intra-peritoneal instillation in laparoscopic cholecystectomy.	8 hours
2.Duration of postoperative analgesia (hours).	8 hours
3.To assess the need of rescue analgesics in post-operative period in all the groups.	8 hours

Secondary Outcome Measures

Name	Time	Method
1.Haemodynamic changes.	2.Any side effects or complications (confusion, dizziness, auditory and visual disturbances, convulsions, hypertension and cardiovascular collapse, tachycardia, arrthymias and respiratory depression).

Locations (1): Govt Medical College Amritsar
🇮🇳
Amritsar, PUNJAB, India
Govt Medical College Amritsar
🇮🇳Amritsar, PUNJAB, India
Dr Joginder Pal
Principal investigator
9501025275
jpattri12@yahoo.co.in