low level laser and osteoarthritis

Phase 3

Completed

• Conditions: aim of this randomized placebo-controlled single-blind clinical trial was to evaluate the short-term efficacy of LLLT on pain alleviation and functional performance in the patients with chronic knee OA; Physical Medicine / Rehabilitation - Physiotherapy; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12612000615886
• Lead Sponsor: Mohammed taher ahmed omar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Patients who had knee OA according to American College of Rheumatology criteria were recruited for the study. All patients had knee OA of grade II or III confirmed radiologically according to the Kellgren-Lawrence grading system. All the patients had a minimum score of 25 on the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) total score. All patients had moderate to great knee pain defined as a score of 4 or greater on visual analogue scale (VAS) in the previous three months. They were willingness to participate and follow the treatment schedule.

Exclusion Criteria

The patients were excluded from the study if they had concomitant disease affecting the knee, such as rheumatoid arthritis, injury and / or surgery to the knee, had received physical therapy and intra-articular corticosteroid or hyaluronic acid injections during the last six months. Furthermore, patients were also excluded if they had history of cancer, dementia, neurological deficits (sensory or motor), heart pacemaker, diabetes mellitus, uncontrolled hypertension, or morbid obesity (BMI less than 40).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome measurement was the pain intensity on Visual Analogue Scale(VAS). <br>Pain Intensity on Visual Analogue Scale: The VAS consists of the 10-cm horizontal line anchored by two extremes of pain: No pain at the left and Worst pain at the right. The patients were provided with a translated Arabic version of VAS, with No pain on the right side and Worst pain on the left side. Patients indicated their current level of pain intensity in their knee (s), and marked this with X on the 10-cm line. Then, the therapist measured the distance between the right side anchor No pain and the mark on the VAS by lying a transparent 10cm ruler over the line. The pain intensity was recorded in centimeters. Pain intensity was recorded at rest and immediately following a 50-foot walking test.[outcome measurements were taken at baseline (W0) and 4-week (W4) after the study was begun.]

Secondary Outcome Measures

Name	Time	Method
The secondary outcomes were knee function in terms of WOMAC scale (WOMAC pain, WOMAC stiffness, WOMAC function).[outcome measurements were taken at baseline (W0) and 4-week (W4) after the study was begun.];the time required to walk distance of 50-feet.The time required to walk a distance of 50-foot as fast as possible was measured with stopwatch and recorded in seconds.[outcome measurements were taken at baseline (W0) and 4-week (W4) after the study was begun.]