NL-OMON50983招募中3 期
Rediscovery of metformin for the chronic disabling auto-inflammatory disease hidradenitis suppurativa - Metformin in HS
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 62
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age >=18 years at baseline
- •A diagnosis of HS for at least 1 year prior to baseline
- •mild to moderately active disease defined by a HS Physician Global Assessment
- •score of 2-3 and the Refined Hurley classification of mild to moderate
- •at baseline
- •Indication for systemic therapy; i.e. uncontrolled disease under conventional
- •topical therapy.
- •Able and willing to give written informed consent and to comply with the
- •study requirements.
排除标准
- •Pregnant and lactating women
- •Previously diagnosed diabetes mellitus and receiving active treatment
- •Use of oral antibiotics within 14 days prior to baseline
- •Use of immunosuppressing/modulating therapies within 28 days prior to baseline
- •A known allergy to metformin or doxycycline or any of the ingredients
- •metformin or doxycycline
- •Contraindications for the use of either metformin (e.g. acute metabolic
- •acidosis, or severe
- •kidney failure with a creatinine clearance < 30 ml/min) or doxycycline
- •(severe liver function
研究者
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