Pregnancy and Implantation Rates When Embryos Are Selected Based on a Single Day 3 Score (Day 3)vs Graduated Embryo Score(GES) Plus Soluble Human Leukocyte Antigen-G Expression.
Overview
- Phase
- Not Applicable
- Intervention
- Human derived FSH
- Conditions
- Infertility
- Sponsor
- University of Stellenbosch
- Enrollment
- 214
- Primary Endpoint
- Pregnancy and implantation rates
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
Detailed Description
Comparing pregnancy rates and implantation rates when embryos are selected using the most common criteria for embryo selection on day 3 - the morphology-(number of blastomere, their shape and size and the percentage of fragmentation)vs a graduated embryo score accumulated over 72 hours and the expression of sHLA-G at 44-46 hours post fertilization.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Self paying ART patients
Exclusion Criteria
- •Abnormal uterus
- •Specific Immunologic factors
Arms & Interventions
A
Embryo selection for transfer based on a Day 3 score only.
Intervention: Human derived FSH
B
Embryos for transfer by first selecting any embryos that had a positive sHLA-G expression of OD = 190 ±6 and correlating such with the highest GES score available.
Intervention: Human derived FSH
Outcomes
Primary Outcomes
Pregnancy and implantation rates
Time Frame: 12 weeks
Secondary Outcomes
- Miscarriage rates(9-11 day until βhCG)