The Effect Of Blood Flow Restrıcted Resistive And Aerobic Exercises in Chronic Obstructive Pulmonary Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- FEV1/FVC rate
研究概览
简要总结
Patients with chronic obstructive pulmonary disease (COPD) classified by a pulmonologist in accordance with the GOLD criteria will be randomly divided into 2 groups.
The first group (n = 20) was accompanied by blood flow restriction (CAC), 3 times a week, 8 weeks, 1RMx 30% intensity, 10 repetitions, 3 sets, 30 seconds rest interval, progressive resistance exercise (PRE) and after 5 minutes of rest by cycling. Progressive aerobic exercise (AE) (BFR PRE + AE group) in the target heart rate range of 50-80% intensity will be applied to the second group (n = 20), PRE and AE (PRE + AE group) performed at the same intensity and duration without BFR.
详细描述
Determination of application groups: Patients with chronic obstructive pulmonary disease (COPD) classified by a pulmonologist in accordance with the GOLD criteria will be randomly divided into 2 groups and application groups will be determined.
Applications to be made:
The first group (n = 20) accompanied by BFR; Progressive resistance training (RT) 3 times a week, 1RMx 30% intensity, 10 repetitions, 3 sets, 30 seconds rest interval, and cycling after 5 minutes rest, progressive aerobic training (AT)in the target heart rate range of 40-80% intensity will be applied.
To the second group (n = 20) without BFR; 3 times a week, 8 weeks, 1RMx 30% intensity, 10 repetitions, 3 sets, 30 seconds of rest interval, and after 5 minutes of rest will be applied in the target heart rate range of 40-80%, which is done by cycling.
Calculation of 1RM: Epley formula will be used in the calculation. According to this; 1 RM = (1 + .0333 x number of repetitions) x weight removed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
40 COPD patients will be randomised divided into two equal groups according to age, gender and disease severity.
入排标准
- 年龄范围
- 40 Years 至 78 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being diagnosed with mild to severe COPD according to GOLD criteria in the age range of 40-78
- •No drug change for at least 30 days
- •Not participating in a structured activity program for at least six months
- •Have the ability to cooperate.
排除标准
- •Presence of any pathology that limits physical activity performance
- •Presence of severe or unstable heart disease
- •Presence of peripheral artery disease
- •Being in an exacerbation period of the disease
- •Presence of another active disease (rheumatic, oncological, traumatic etc.)
- •Any neurological or orthopedic disease that prevents exercise
研究组 & 干预措施
Blood Flow Restricted Aerobic and Resistance Exercise Group
kan akımı kısıtlanarak.direnç ve bisikletle aerobik egzersiz uygulanacak
干预措施: Blood flow restricted and normal aerobic exercise and resistance exercise (Procedure)
Normal aerobik ve direnç egzersiz grubu
Normal şartlarda aerobik ve direnç egzersizi uygulanacak
干预措施: Blood flow restricted and normal aerobic exercise and resistance exercise (Procedure)
结局指标
主要结局
FEV1/FVC rate
时间窗: eight weeks
respiratory function test
total antioxidant status
时间窗: eight weeks
oxidative stress marker
oxygen saturation
时间窗: three times a week
blood gas test
six minute walk test
时间窗: eight weeks
strength evaluation
c reactive protein
时间窗: eight weeks
thrombus formation risk marker
heart rate
时间窗: three times a week
for exercise dose determination
ST george's respiratory questionnaire
时间窗: eight weeks
used to evaluate the effects of respiratory disease's symptoms and illness
quadriceps muscle diameter
时间窗: eight weeks
Measurement of change in muscle volume
creatine kinase
时间窗: eight weeks
muscle breakdown marker
d-dimer
时间窗: eight weeks
venous thromboembolism marker
total oxidant status
时间窗: eight weeks
oxidative stress marker
interleukin 6
时间窗: eight weeks
inflammation marker
次要结局
未报告次要终点
研究者
Ahmet Gunes
PhD Student
Medipol University