Intra-bone marrow injection of cord blood following reduced-intensity conditioning: A phase II study
Phase 2
- Conditions
- Refractory hematologic malignancies (acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndrome, malignant lymphoma)
- Registration Number
- JPRN-UMIN000006529
- Lead Sponsor
- Hyogo College of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1) Allergy for the agents used in conditioning or GVHD prophylaxis 2) Patients who are considered as inappropriate with other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of donor cell engraftment (>90% of donor origin)
- Secondary Outcome Measures
Name Time Method Incidence of severe GVHD Incidence and severity of chronic GVHD Disease free survival at 1 year after transplantation Treatment related mortality within 1 year after transplantation Incidence of infections (bacteria, fungus, virus, etc) Immune reconstitution after transplantation