PROMINENT Smoking Cessation Study

Not Applicable

• Conditions: ung cancer; Cancer

• Registration Number: ISRCTN12925323
• Lead Sponsor: niversity of Manchester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-02
• Last Update Posted: 9 September 2024
• Study Completion: 2027-05-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. ALL
1.1. Self-reported current cigarette smoker
1.2. Carbon Monoxide (CO) reading >=5 ppb
1.3. Intends to quit smoking / undertake a smoking quit attempt within 3 months
1.4. No prior history of cancer
1.5. Able to provide informed consent

2. Lung Health Check attendees
2.1. Aged >=55 years
2.2. PLCOM2012 score >=1.51% (or eligible for screening if alternative risk model is used)

3. MFT-CURE attendees
3.1. Aged >=40 years

Exclusion Criteria

1. All
1.1. Never or former smoker (has not smoked within the last 2 weeks)
1.2. Carbon Monoxide (CO) reading <5 ppb
1.3. Prior history of cancer

2. Lung Health Check attendees
2.1. Aged <55 years
2.2. Decline or unable to undertake LDCT screening

3. MFT-CURE attendees
3.1. Aged <40 years

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Molecular signals measured by molecular signature as observed in mouth and nose samples, at baseline and follow-up (9 – 12 months)

Secondary Outcome Measures

Name	Time	Method
There are no secondary outcome measures