High Intensity interval Training after Cardiac Resynchronization Therapy.
- Conditions
- Chronic Heart FailureCardiac Resynchronization TherapyHigh Intensity Training
- Registration Number
- NL-OMON22642
- Lead Sponsor
- one
- Brief Summary
Kemps HM, Schep G, De Vries WR et al. Predicting effects of exercise training in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2008;102:1073-1078. <br><br> Kemps HM, De Vries WR, Hoogeveen AR, Zonderland ML, Thijssen EJ, Schep G. Reproducibility of onset and recovery oxygen uptake kinetics in moderately impaired patients with chronic heart failure. Eur J Appl Physiol 2007;100:45-52. <br><br> Kemps HM, Schep G, Hoogsteen J et al. Oxygen uptake kinetics in chronic heart failure: clinical and physiological aspects. Neth Heart J 2009;17:238-244.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
1. Written informed consent;
2. Systolic heart failure due to ischemic cardiomyopathy (due to one or more myocardial infarction, as confirmed with echocardiography) or dilating cardiomyopathy (no history of myocardial infarction, no proven ischemia, no congenital heart disease en no severe valve disorder);
1. Myocardial infarction or unstable angina less than 3 months prior to inclusion;
2. Clinical signs of decompensated heart failure;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in peak VO₂ after 3 months of HIT in CHF patients that underwent CRT as compared to a control group that received no training.
- Secondary Outcome Measures
Name Time Method Training-induced changes in:<br /><br>1. Left ventricular function assessed by left ventricular ejection fraction and end systolic volume;<br /><br>2. Submaximal exercise capacity assessed by the rate of recovery of oxygen uptake after submaximal exercise (time constant of recovery, tau-rec);<br /><br>3. Quality of life assessed by the Minnesota living with heart failure Questionnaire;<br /><br>4. Plasma NT-pro BNP, a prognostic biomarker of heart failure.