The Influence of Different At-home Exercise Strategies on 24h Glycemic Control in Women at Risk for With Metabolic Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Toronto
- Enrollment
- 107
- Locations
- 1
- Primary Endpoint
- 24hr Glucose area under the curve
Study Overview
Brief Summary
This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.
Detailed Description
Elevations in blood glucose concentration increase risk for cardiometabolic diseases including type 2 diabetes and cardiovascular diseases. Exercise can improve glycemic control, but there is limited research comparing the effectiveness of different exercise strategies in women. The aim of this study is to examine, under free-living conditions, how performing either walking and bodyweight interval exercise after dinner influences glycemic control in women with or at risk for type 2 diabetes. Glycemic control will be measured with continuous glucose monitors.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •no cancer history
- •≥50 years old
- •Have metabolic dysfunction (defined as self-reported diagnosis of pre-diabetes, type 2 diabetes, or at least moderate Canadian diabetes risk (CANRISK) score)
- •Owns a smartphone with Bluetooth capability with Apple or Android operating system
- •deemed safe to exercise as per the CSEP Get Active Questionnaire
- •Enrolled in NCT05454943
Exclusion Criteria
- •Type 1 diabetes
- •Taking exogenous insulin, sulfonylureas, or GLP-1 receptor agonists
- •Self-reported history of an eating disorder
- •BMI <18.5 kg/m
- •Working night or rotating shifts
- •Eating window <12 hours or consistently eating less than 3 meals/day in the past 3 months
- •Major dietary changes within the past 3 months (i.e. calorie counting, ketogenic diet)
Arms & Interventions
Bodyweight interval exercise
Performing 15 minutes of bodyweight interval exercise after dinner
Intervention: Bodyweight interval exercise (Behavioral)
Walking
Performing a 30 minute walk after dinner
Intervention: Walking (Behavioral)
Non exercise control
Performing no exercise after dinner
Outcomes
Primary Outcomes
24hr Glucose area under the curve
Time Frame: 24 hours
Glucose area under the curve over 24hr
Secondary Outcomes
- 24hr Average glucose concentration(24 hours)
- Time in hyperglycemia(24 hours)
- Postprandial dinner glucose response(2 hours)
- Nocturnal glucose(~6-8 hours)
- Postprandial breakfast glucose response(2 hours)
- Postprandial lunch glucose response(2 hours)
- Time in hypoglycemia(24 hours)
- Time in range(24 hours)
- Change in glucose during exercise(15-30 minutes)
- Standard deviation (SD)(24 hours)
- Continuous overall net glycemic action (CONGA)(24 hours)
- Mean amplitude glycemic excursion (MAGE)(24 hours)
- % coefficient of variation (CV)(24 hours)
Investigators
Jenna Gillen
Assistant Professor
University of Toronto