Endothelial Cell Activation and Total Pulmonary Resistance in PAH

Not Applicable

Not yet recruiting

• Conditions: Pulmonary Artery Hypertension
• Interventions: Drug: XBD173

• Registration Number: NCT06035861
• Lead Sponsor: Imperial College London

Brief Summary

To determine whether changes in endothelial cell dysfunction are associated with changes in total pulmonary resistance in patients with pulmonary arterial hypertension

Detailed Description

Patients with PAH will be exposed to XBD173. Markers of endothelial cell dysfunction and activation will be measured in the plasma, and changes in total pulmonary resistance will be meausured with an implantable monitor

Study Timeline

• Study First Submitted: 2023-08-30
• Study First Submitted QC: 2023-09-06
• Study First Posted: 2023-09-13
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-17
• Last Update Posted: 2024-10-18
• Study Start: 2024-11-01
• Primary Completion: 2026-10-31
• Study Completion: 2026-10-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

1. Subjects aged between 18-75 years old
2. PAH which is: idiopathic; PAH heritable; PAH associated with connective tissue disease; PAH after ≥ 1 year repair of congenital systemic to pulmonary shunt; or PAH associated with anorexignes or other drugs.
3. Resting mean pulmonary artery pressure ≥25 mmHg, pulmonary capillary wedge pressure ≤15 mmHg, PVR >5 wood units, and normal or reduced cardiac output, as measured by a previous right heart catheterisation (RHC).
4. Have an insertable FDA/CE cardiac rhythm monitor and pulmonary artery pressure monitor that captures cardiopulmonary haemodynamics and daily activity.
5. Six-minute walking distance >50m at entry
6. Stable on an unchanged PAH therapeutic regime comprising at least 2 therapies licensed for PAH (any combination of endothelin receptor antagonist, phosphodiesterase inhibitor or prostacyclin analogue) for at least 1 month prior to screening
7. Subjects willing to be genotyped for genes that influence XBD173 activity
8. Able to provide written informed consent prior to any study mandated procedures
9. Contraception: Fertile females (women of childbearing potential) are eligible to participate after a negative highly sensitive pregnancy test, if they are taking a highly effective method of contraception other than the oral contraceptive pill during treatment and until the end of relevant systemic exposure

Exclusion Criteria

1. Unable to provide informed consent and/or are non-fluent speakers of the English language

2. Hypersensitivity to XBD173 or to any of the excipients

3. Clinically-significant renal disease (confirmed by creatinine clearance <30 ml/min per 1.73m2)

4. Clinically-significant liver disease (confirmed by serum transaminases >2 times than upper normal limit)

5. Anaemia confirmed by haemoglobin concentration <10 g/dl

6. Individuals known to have haemoglobinopathy sickle cell disease, thalassaemia

7. Hospital admission related to PAH or change in PAH therapy within 3 months prior to screening

8. History of left-sided heart disease and/or clinically significant cardiac disease, including but not limited to any of the following:

   1. Aortic or mitral valve disease (stenosis or regurgitation) defined as greater than mild aortic insufficiency, mild aortic stenosis, mild mitral stenosis, moderate mitral regurgitation
   2. Mechanical or bioprosthetic cardiac valve
   3. Pericardial constriction, effusion with tamponade physiology, or abnormal left atrial size.
   4. Restrictive or congestive cardiomyopathy
   5. Left ventricular ejection fraction ≤50% (measured in echocardiogram at screening)
   6. Symptomatic coronary disease
   7. Significant (2+ for regurgitation) valvular disease other than tricuspid or pulmonary regurgitation
   8. Acutely decompensated left heart failure within 1 month of screening
   9. History of untreated obstructive sleep apnoea

9. Evidence of significant lung disease on high-resolution CT (if available) or recent (performed within 12 months) lung function, where FEV1 < 50% predicted and FVC < 70% predicted, and DLCO (or TLCO) < 50% predicted if any CT abnormalities; judged by the Site Physician

10. Patients with a history of uncontrolled systemic hypertension

11. Acute infection (including eye, dental, and skin infections)

12. Chronic inflammatory disease including HIV, and Hepatitis B

13. Women of childbearing potential who are pregnant or breastfeeding (if applicable)

14. Patients who have received an Investigational Medicinal Product (IMP) within 5 half-lives of the last dose of the IMP or 1 month (which ever is greater) before the baseline visit

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
XBD173	XBD173	6 weeks exposure to XBD173

Primary Outcome Measures

Name	Time	Method
Percentage change in plasma sVCAM1, e-selectin, GDF-15 and NT-proBNP	6 weeks	Percentage change in plasma markers
Percentage change in total pulmonary resistance	6 weeks	Percentage change in total pulmonary resistance