The effects of Daikenchuto for the tretment of constipation in the patients with cerebrovascular diseases
- Conditions
- cerebrovascular diseases with constipation
- Registration Number
- JPRN-UMIN000007393
- Lead Sponsor
- Tohoku University
- Brief Summary
Poststroke patients with functional constipation, assessed by the Rome III criteria, from 6 hospitals were recruited in a study on the effects of the traditional Japanese medicine Daikenchuto (DKT) on constipation. Thirty-four patients (17 men and 17 women; mean age: 78.1 years) were randomly assigned to 2 groups; all patients received conventional therapy for constipation, and patients in the DKT group received 15g/day of DKT for 4 weeks. Constipation scoring system (CSS) points and the gas volume score (GVS) (the measure of the intestinal gas volume calculated from plain abdominal radiographs) were recorded before and after a 4-week observation period. The total score on the CSS improved significantly in the DKT group compared to the control (p < 0.01 ). In addition, scores for some CSS subcategories (frequency of bowel movements, feeling of incomplete evacuation, and need for enema/disimpaction) significantly improved in the DKT group (p < 0.01, p = 0.049, and p = 0.03, resp.). The GVS was also significantly reduced in the DKT group compared to the control ( p = 0.03). DKT in addition to conventional therapy is effective in treating functional constipation in poststroke patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Not provided
Patients with malignancy Patients with severe liver, heart, and renal diseases Loss of consciousness Patients who have already treated by Daikenchuto
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of clinical score of constipation
- Secondary Outcome Measures
Name Time Method