Transcranial Direct Current Stimulation Aided Rehabilitation of Gait in Subacute Stroke

Not Applicable

Terminated

• Conditions: Stroke; Neurorehabilitation
• Interventions: Device: Transcranial Direct Current Stimulation

• Registration Number: NCT01927458
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to determine if transcranial direct current stimulation (tDCS)applied over the lower extremity motor cortex in conjunction with treadmill training is effective for improving gait in patients with subacute stroke and to evaluate the effect and predictive value of a single session of anodal tDCS.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-08-15
• Study First Submitted QC: 2013-08-19
• Study First Posted: 2013-08-22
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-04
• Last Update Posted: 2017-02-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Age ≥ 18 years
• Onset of stroke less than 14 days
• First ischemic stroke causing lower limb weakness (MRC score ≤4 in knee extensors) and gait impairment

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Exclusion Criteria

• Contraindications to MRI or TMS
• Other neurological disorders
• Significant somatic or psychiatric disorders
• History of seizures
• Language or cognitive disorders prohibiting participation

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
anodal tDCS with treadmill training	Transcranial Direct Current Stimulation	Each subject will receive 4 weeks gait treadmill training at least 3 days per week in combination with anodal transcranial Direct Current Stimulation over the primary motor cortex up to 20 min

Primary Outcome Measures

Name	Time	Method
Maximal gait speed using the 10-m walking test	Baseline and follow up immediately following the 4 weeks intervention

Secondary Outcome Measures

Name	Time	Method
Changes in cortical excitability measures	Baseline	We will measure cortical excitability using single pulse transcranial magnetic stimulation (TMS) before and after 1st stimulation session. We will compare the measurements from before stimulation to after stimulation.
Dynamometry: the maximal isometric force of muscles will be assessed by Biodex System 3 PRO dynamometer	Baseline and immediately following the 4 weeks intervention

Trial Locations

Locations (1)

Hammel Neurocenter; 🇩🇰 Hammel, Denmark