Evaluation of hand function in patients with Duchenne muscular dystrophy, including an additional pilot study with a newly designed glove. An explorative study.

Completed

Conditions: Duchenne disease
Duchenne muscular dystrophy
10029317

Registration Number: NL-OMON41821

Lead Sponsor: Revalidatiegeneeskunde

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

A DNA-established diagnosis of DMD
Informed consent

Exclusion Criteria

Presence of other disabling disease(s) with (major) influence on strength, mobility or activities, especially concerning the hand.
Unable to cooperate with or understand testing

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary goal of this study is to examine the natural disease course in the<br /><br>hands of persons with DMD. We will evaluate two different levels of human<br /><br>functioning according to the International Classification of Functioning,<br /><br>Disability and Health (ICF) model; the dimension of body function and<br /><br>structures as well as the dimension of activities.<br /><br>To measure strength and function we will use the recently developed tools<br /><br>MyoPinch, MyoGrip and MOVIPLATE. To assess the presence of contractures we will<br /><br>measure range of motion using goniometry. To evaluate and describe activities<br /><br>we will use several instruments, including Brooke, MACS, PUL, Timed-TIHM and<br /><br>CUE. We will perform an additional pilot in 5 to 15 patients where we will<br /><br>measure hand kinematics with a recently designed glove (TU Twente). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary goals of this study are to explore relations between these two<br /><br>levels, the possible difference between the dominant and non-dominant hand, and<br /><br>possible influence of posture and/or training or splints.</p><br>