Dairy Food Consumption and Its Effects on Inflammation and the Postprandial Regulation of Muscle Protein Synthesis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Blood inflammation markers by flow cytometry.
研究概览
简要总结
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction. As such, obesity programs should not only focus on weight loss, but muscle metabolic health. Dairy nutrients have anti-inflammatory and anabolic properties, but mostly evaluated in isolation and/or pre-clinical designs. Also, it is unknown if the circulating benefits extend to the muscle. We hypothesize that dairy full-fat milk will improve these obesity characteristics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Obese (BMI, body mass index ≥30, <40 kg•m-2)
- •Age 40-59
- •Pre-menopausal
- •Sedentary/insufficiently active for prior 6 months (mo)
- •Weight stable for prior 6 mo
排除标准
- •Tobacco, nicotine (patch/gum) use (previous 6 mo)
- •Alcohol consumption >10 drinks per week
- •Metabolic disorders (e.g., Metabolic Syndrome, Diabetes, thyroid diseases)
- •Cardiovascular disease, arrhythmias
- •Hypogonadism
- •History of uncontrolled hypertension
- •Orthopedic injury/surgery (within 1 yr)
- •Hepatorenal, musculoskeletal, autoimmune, or neurological disease
- •History of neuromuscular problems
- •Previous participation in amino acid tracer studies
- •Predisposition to hypertrophic scarring or keloid formation
- •Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation
- •Consumption of thyroid, androgenic, or other medications known to affect endocrine function
- •Consumption of medications known to affect protein metabolism (e.g., prescription-strength corticosteroids, non-steroidal anti-inflammatories, or acne medication)
- •Pregnancy
- •Allergy to dairy product or lactose intolerance
- •Fasting plasma glucose (FPG) ≥ 126 mg/dL
- •Oral glucose tolerance test (OGTT) ≥ 200 mg/dL
结局指标
主要结局
Blood inflammation markers by flow cytometry.
时间窗: 1 week observation period to respective Arm within a controlled-feeding intervention.
Measurement of blood cytokines, monocytes, and macrophages by flow cytometry before and after 1-week of 3 daily servings of respective dairy treatment within a controlled-feeding intervention.
Fractional synthetic rate of myofibrillar proteins by stable isotope infusion.
时间窗: 0-5 hours postprandial observation period to ingesting 2 servings of respective Arm.
Refers to rate of building new proteins in skeletal muscle contractile protein fraction. Myofibrillar protein synthesis rates will be assessed during stable isotope infusion whereby participants will ingest 2 servings of their respective dairy treatment and the postprandial response is compared between the Arms.
次要结局
未报告次要终点
研究者
Nicholas Burd
Associate Professor
University of Illinois at Urbana-Champaign