Efficacy of vitamin A and zinc supplementation on pathogen-specific diarrheal disease.
Not Applicable
Completed
- Conditions
- Paediatric diarrhoeal diseaseInfection - Studies of infection and infectious agentsOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colonInflammatory and Immune System - Normal development and function of the immune system
- Registration Number
- ACTRN12612000497808
- Lead Sponsor
- niversity of Queensland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 800
Inclusion Criteria
Children 6-15 months of age living in peri-urban communities of Mexico City
Exclusion Criteria
Children with immuno-suppression or any congenital or acquried alteration of the digestive tract that could alter the absorption of micronutrients were excluded. Children were also excluded when they had received a vitamin A supplement from a source outside the project.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How do vitamin A and zinc modulate retinoic acid signaling and zinc transporter proteins in pathogen-specific pediatric diarrhea (ACTRN12612000497808)?
What is the comparative efficacy of vitamin A and zinc supplements versus standard-of-care oral rehydration therapy for rotavirus-induced diarrhea in children?
Which immune-related biomarkers, such as cytokine profiles or gut microbiota diversity, predict response to vitamin A and zinc supplementation in ACTRN12612000497808?
What are the potential adverse events of high-dose vitamin A and zinc in young children with diarrheal disease, and how are they managed in clinical trials?
Are there synergistic effects between vitamin A, zinc, and probiotics in reducing pathogen-specific diarrhea recurrence rates in ACTRN12612000497808?