Bone Disease in Severely Burned Children
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 254
- 试验地点
- 1
- 主要终点
- Determine Bone Health(bone growth,strength,and content) in burn injured patients.
研究概览
简要总结
Bone metabolism is adversely affected by severe burns in children for a period of time.
详细描述
More closely monitored biochemical and radiologic parameters of bone and mineral metabolism will increase the likelihood of earlier detection of abnormalities and possible therapeutic interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children age 5-18 years old with at least 40% or more of their body burned.
排除标准
- •Anyone with a burn covering less than 40% of the body or whose burn covers the front of both hipbones.
- •Anyone younger than 5 years old, anyone with a history of cancer or other metabolic disease process, or anyone who is pregnant or has an allergy to Tetracycline will also be excluded.
- •Anyone who has participated in an investigational drug trial within the past 60 days from date of admission will be excluded from this study.
研究组 & 干预措施
1
Compare bone density of severly burned children to normal non-burned population
干预措施: Tetracycline (Drug)
1
Compare bone density of severly burned children to normal non-burned population
干预措施: Duel Energy X-Ray Absorptiometry (DEXA) (Radiation)
1
Compare bone density of severly burned children to normal non-burned population
干预措施: Bone Biopsy (Procedure)
结局指标
主要结局
Determine Bone Health(bone growth,strength,and content) in burn injured patients.
时间窗: Admission to Burn Unit up to eighteen years old.
次要结局
未报告次要终点