Evaluation of choline levels in gall bladder carcinoma using magnetic resonance spectroscopy.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Establish the co-relation between choline levels peak and likelihood of metastasis of Ca Gallbladder at the site of Choline Peak with the help of MR Spectroscopy.
研究概览
简要总结
Gallbladder carcinoma is a relatively rare but highly aggressive malignancy of the biliary tract with poor prognosis mainly due to its often late diagnosis and limited treatment options. Early detection and accurate staging of GBC are crucial for improving patient outcome. MRI have shown promise in enhancing accuracy and prognostic values in GB carcinoma patients. MRS enables the non-invasive assessment of metabolites levels within tissues offering insights into cellular metabolites and providing biomarkers for cancer detection and characterization. One such metabolite of interest is choline, a component of cell membrane whose elevation levels has been associated with increased cell proliferation and malignant transformation. Therefore this study will aim to investigate the role of MRI and MR spectroscopy in evaluating choline levels in GB carcinoma patients to improve early detection and guide personalized treatment for this aggressive malignancy.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •To study the spectrum of MRI findings in gall bladder carcinoma.
- •To determine the choline levels under MR Spectroscopy in gall bladder carcinoma.
排除标准
- •A patient who had surgery or medical care in the past.
- •Women who are pregnant.
- •Patients with pacemakers, cochlear implants, or metallic implants.
- •Patients with any type of psychological condition including claustrophobia.
- •Patients who are unwilling or uncooperative.
结局指标
主要结局
Establish the co-relation between choline levels peak and likelihood of metastasis of Ca Gallbladder at the site of Choline Peak with the help of MR Spectroscopy.
时间窗: All patients will be assessed at the end of 3 months.
次要结局
- To explore the potential of MR spectroscopy in detecting choline levels as a biomarker for gall bladder carcinoma.(All patients will be assessed at the end of 3 months.)
研究者
Dr Anjali Kumari
Jawaharlal Nehru Medical College(Datta meghe institute of higher education and research)