A Single-Center, Prospective, Observational Registry Cohort Study to Investigate Aging-Related Biomarkers, Prognosis, and Risk Prediction in Patients With Acute Myocardial Infarction
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Major adverse cardiovascular events (MACE)
研究概览
简要总结
This is a single-center, prospective, observational cohort study designed to investigate the association between aging-related characteristics and long-term outcomes in patients with acute myocardial infarction (AMI). Approximately 588 eligible participants will be consecutively enrolled and followed for at least 24 months. Clinical data, aging assessments, laboratory examinations, cardiac imaging, and blood samples will be collected to establish a clinical database and biobank. The study aims to identify aging-related prognostic biomarkers, develop a risk prediction model integrating clinical and aging-related indicators, and improve risk stratification and individualized management for patients with AMI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1. Age ≥ 60 years old and meet the above comprehensive aging assessment criteria (i.e., combined with at least one clinical phenotype of aging and abnormal blood aging markers on the basis of advanced age);
- •Acute myocardial infarction occurs for ≥ 3 months;
- •Meet the diagnostic criteria for AMI in accordance with the Fourth Edition General Definition of Myocardial Infarction;
- •The patient or their legal representative signs an informed consent form.
排除标准
- •1. Newly diagnosed acute myocardial infarction, angina pectoris, stroke or transient ischemic attack within the past 3 months;
- •Serious life-threatening diseases (such as advanced malignant tumors, end-stage kidney disease/liver disease, severe infections) with an estimated lifespan of less than 1 year;
- •Severe cognitive impairment, mental illness, inability to cooperate in completing follow-up, aging assessment, and related examinations;
- •Unable to complete assessment items such as grip strength, walking speed, and 6-minute walk test due to non cardiac reasons such as physical disabilities and severe bone and joint diseases;
- •Failed to sign the informed consent form.
结局指标
主要结局
Major adverse cardiovascular events (MACE)
时间窗: Baseline through 24 months of follow-up
The occurrence of major adverse cardiovascular events, including all-cause death, cardiovascular death, recurrent myocardial infarction, hospitalization for heart failure, stent restenosis or thrombosis, severe bleeding, and aging-related serious adverse events.
次要结局
- All-cause mortality(Baseline through 24 months)
- Cardiovascular mortality(Baseline through 24 months)
- Hospitalization for heart failure(Baseline through 24 months)
- Recurrent myocardial infarction(Baseline through 24 months)
- Aging-related serious adverse events(Baseline through 24 months)
- Prognostic performance of the aging-related risk prediction model(At completion of the 24-month follow-up)