Blood sugar control after bypass operation - insulin vs oral medicatio
Not Applicable
Recruiting
- Conditions
- heart disease, diabetes
- Registration Number
- SLCTR/2014/024
- Lead Sponsor
- ational Hospital of Sri Lanka
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 330
Inclusion Criteria
1. Patients with type 2 diabetes admitted to Cardio-thoracic units of the National Hospital of Sri Lanka for coronary artery bypass grafting (CABG)
2. Daily insulin requirement of <1IU/kg/day to achieve satisfactory glycaemic control
Exclusion Criteria
1. Patients on insulin prior to admission due to oral hypoglycaemic (OHG) failure
2. Daily insulin requirement following CABG >1IU/kg/day.
3. Serum creatinine > 1.5 mg/dl
4. Unstable cardiac failure
5. Chronic liver disease
6. Patients taking drugs affecting glycaemic control (eg. Steroids)
7. Patients unable to return for follow-up
8. Patients who are unable to understand or cooperate with protocol requirements
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. HbA1c<br>2. FBG<br>3. PPBG<br> [1. HbA1c will be done at 3 months after discharge<br>2. FBG and PPBG will be done at one week, one month, two months and three months after discharge ]<br>
- Secondary Outcome Measures
Name Time Method 1. Surgical wound infection occurring within 30 days of surgery (at least one of the following: purulent discharge from surgical site or drain, organisms isolated from aseptically obtained wound culture, signs and symptoms of infection such as pain or tenderness, localized swelling, or redness/heat).<br><br>2. Acute coronary syndrome: Angina associated with dynamic ECG changes and or raised troponin levels <br><br>3. Heart failure<br><br>4. Stroke<br><br>5. Hypoglycaemia (RBG < 70 mg/dL or 3.9 mmol/L)<br><br>6. Weight change (5% weight loss or gain over three months) [Monthly after discharge for 3 months]<br>