Evaluating an HIV Risk Screening Tool for Use in a Population of Orphans and Other Vulnerable Children in Tanzania
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21,080
- 试验地点
- 1
- 主要终点
- Specificity of HIV risk screening tool
研究概览
简要总结
The goal of the research was to evaluate the performance of items within the Kizazi Kipya (K2) Orphan and Vulnerable Children (OVC) HIV risk screening tool in identifying HIV-positive children, to optimize an HIV screening tool for OVC and children and adolescents in facility settings and to assess the feasibility and acceptability of home-based HIV risk screening and testing.
详细描述
Under the ongoing community-based Kizazi Kipya (K2) OVC project, program staff currently administer a 13-item HIV risk screening tool to all K2 program beneficiaries, and refers those who screen positive to facility-based HIV testing. A subset of this 13-item tool is a module of four items that had previously been used as a standalone four-question screening tool in facilities in Zimbabwe.
The primary objectives of this study are as follows.
- To evaluate the performance of a lay cadre-administered four-item subset of the K2 HIV risk screening tool that matches the Zimbabwe evidence-based tool in predicting the HIV status of vulnerable children/adolescents represented by two populations: (a) K2 OVC beneficiaries and (b) children/adolescents attending health facilities.
- To identify additional items in the K2 HIV risk screening tool that could be added to the four-question subset to improve the tool's performance.
- To assess fidelity to the administration of the OVC HIV screening tool items through structured observations of community case workers in the K2 program.
- To assess the acceptability of OVC HIV risk screening and testing implemented in the community among OVC beneficiaries in the K2 program.
- To assess the acceptability and feasibility of integrating the OVC HIV screening tool with HIV testing among OVC community case workers in the K2 program.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 2 Years 至 19 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Living in a household deemed to be at elevated HIV risk based on previously identified risk criteria
- •Attending a study health facility in two regions of Tanzania
- •Age 2-19 years
排除标准
- •Previously tested HIV-positive
- •History of antiretroviral treatment (ART)
- •Unable or unwilling to be consented
- •Age 5-19 years old, tested negative in past 6 months, and having no reported exposure to HIV through sexual contact (consensual, abuse) or through blood transfusion/needle injury.
- •Community care workers:
- •Inclusion criteria:
- •conducting HIV risk screening in OVC households as part of their role in the Kizazi Kipya project in the subset of study districts where structured observations and focus group discussions were conducted
- •Exclusion criteria:
- •unwilling to consent to the study
结局指标
主要结局
Specificity of HIV risk screening tool
时间窗: Within four weeks
Children/adolescents testing HIV negative on the tool who are truly HIV negative
Sensitivity of HIV risk screening tool
时间窗: Within four weeks
Children/adolescents testing HIV positive on the tool who are truly HIV positive
Positive predictive value
时间窗: Within four weeks
Proportion of children/adolescents testing positive on the tool who actually have HIV
Negative predictive value
时间窗: Within four weeks
Proportion of children/adolescents testing negative on the tool who do not actually have HIV
Acceptability of HIV risk screening tool
时间窗: Within six weeks
Examining the extent of reception of the screening tool by the OVC caregivers and the community case workers using a semi-structured questionnaire
Feasibility of HIV risk screening tool
时间窗: Within six weeks
Exploring the practicality of use of HIV risk screening tool through focus group discussions with community case workers
次要结局
未报告次要终点