The Effect of Preoperative Intravenous Fluid Bolus on Post-induction Hypotension in Elective Cystoscopies.
Phase 4
- Conditions
- Postinduction HypotensionHypotension During Surgery
- Interventions
- Registration Number
- NCT06985654
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
This study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (PIH) in patients undergoing cystoscopy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Age ≥ 18 years old.
- Undergoing elective cystoscopy surgery as the primary procedure.
- Able to provide informed consent.
Exclusion Criteria
- Emergency surgeries.
- Past history of amputations of any body part.
- Allergies or contraindications to any medications used in the protocol or lactated ringers.
- Systolic heart failure with LVEF < 30% within the last year.
- Severely depressed RV function within the last year.
- Restrictive diastolic dysfunction within the last year.
- Currently pregnant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Preoperative Fluid Bolus Lactated Ringers Patients will receive an ultrasound scan on their heart to determine cardiac output and will also receive a fluid bolus of Lactated Ringers before surgery.
- Primary Outcome Measures
Name Time Method Incidence of Postinduction Hypotension From the time patient enters the operating room to the end of surgery, assessed up to 24 hours. Number of patients that experience a decrease in mean arterial pressure (MAP) greater than 20% from the baseline MAP.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie Lactated Ringers' efficacy in preventing post-induction hypotension during cystoscopy?
How does preoperative crystalloid bolus compare to standard-of-care fluids like normal saline in reducing PIH incidence in urological procedures?
Which biomarkers correlate with volume responsiveness to preoperative fluid administration in patients at risk for intraoperative hypotension?
What are the potential adverse events of preoperative Lactated Ringers bolus and strategies for managing fluid-related complications?
Are there alternative intravenous fluids or combination therapies with vasopressors that outperform Lactated Ringers in preventing hypotension during cystoscopy?
Trial Locations
- Locations (1)
University Hospital
🇺🇸Columbia, Missouri, United States
University Hospital🇺🇸Columbia, Missouri, United StatesSagar Bansal, MDContact(573) 882-2568sagar.bansal@health.missouri.edu