NCT04169022CompletedNot Applicable
Targeting Interleukin 1 Receptor Accessory Protein (IL1RAP) Expressing Acute Myeloid Leukemic (AML) Cells by Chimeric Antigen Receptor (CAR) Engineered T-cells
Centre Hospitalier Universitaire de Besancon2 sites in 1 country86 target enrollmentStarted: July 10, 2019Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 86
- Locations
- 2
- Primary Endpoint
- IL1RAP protein expression
Study Overview
Brief Summary
AML is one of the most aggressive forms of leukemia, where bone marrow transplantation remains the gold standard treatment, with its known associated toxicities and related mortality. Despite progress in the treatment of leukemic malignancies, especially the emergence of targeted- and immuno-therapies arising from biological genomic knowledge, there remains a need to provide additional strategies for refractory/relapsing (R/R) patients
Aim of this study is to collect biological samples of AML patients in order to validate our Chimeric Antigen Receptor T-cells immunotherapy approach
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Screening
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •AML patients adults and pediatrics
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
IL1RAP protein expression
Time Frame: 2 years
Cytometry analysis
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (2)
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