Fluid Treatment and the Impact of Gender in a Septic Population
试验速览
- 阶段
- 不适用
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Gender differences in fluid treatment
研究概览
简要总结
In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. About 11 000 patients will be included. Patient data including fluid therapy will be drawn from the electronic medical record; Take Care and Clinisoft. In the logistic regression analysis, the investigators will adjust for age, gender, comorbidities, vital signs, preliminary focus of infection, level of care and renal replacement therapy. The aim is to analyze gender differences in fluid treatment and the response to fluid treatment and if the treatment is associated with differences in mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted to the emergency department with suspected sepsis (defined by blood culture taken and intravenous sepsis-antibiotics prescribed within 48 hours) and fulfilling sepsis-3 definition of sepsis (sequential organ failure assesment score of 2 or more)
排除标准
- •Patients transferred from other hospitals or treatment clinics.
结局指标
主要结局
Gender differences in fluid treatment
时间窗: Fluid therapy during the first six hours (adherence to sepsis bundles) and the first five days after admission.
Millilitres of fluid given per kilogram of patient weight (ml/kg).
次要结局
- Type of fluids(First five days after admission.)
- Association between fluid therapy and need for/ dose of vasopressors/inotropic drugs(First five days efter admission)
- Association between fluid therapy and levels of lactat(First five days efter admission)
- Association between amount of fluid and mortality(In-Hospital Mortality, 30- and 90-days mortality)
研究者
Christer Svensen
Professor
Karolinska Institutet