Fluid Treatment and the Impact of Gender in a Septic Population
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- Karolinska Institutet
- Enrollment
- 5000
- Locations
- 1
- Primary Endpoint
- Gender differences in fluid treatment
- Last Updated
- 5 years ago
Overview
Brief Summary
In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. About 11 000 patients will be included. Patient data including fluid therapy will be drawn from the electronic medical record; Take Care and Clinisoft. In the logistic regression analysis, the investigators will adjust for age, gender, comorbidities, vital signs, preliminary focus of infection, level of care and renal replacement therapy. The aim is to analyze gender differences in fluid treatment and the response to fluid treatment and if the treatment is associated with differences in mortality.
Investigators
Christer Svensen
Professor
Karolinska Institutet
Eligibility Criteria
Inclusion Criteria
- •Patients admitted to the emergency department with suspected sepsis (defined by blood culture taken and intravenous sepsis-antibiotics prescribed within 48 hours) and fulfilling sepsis-3 definition of sepsis (sequential organ failure assesment score of 2 or more)
Exclusion Criteria
- •Patients transferred from other hospitals or treatment clinics.
Outcomes
Primary Outcomes
Gender differences in fluid treatment
Time Frame: Fluid therapy during the first six hours (adherence to sepsis bundles) and the first five days after admission.
Millilitres of fluid given per kilogram of patient weight (ml/kg).
Secondary Outcomes
- Type of fluids(First five days after admission.)
- Association between fluid therapy and need for/ dose of vasopressors/inotropic drugs(First five days efter admission)
- Association between fluid therapy and levels of lactat(First five days efter admission)
- Association between amount of fluid and mortality(In-Hospital Mortality, 30- and 90-days mortality)