A pilot study on the effect of niacin on pulmonary arterial pressure

Not Applicable

Completed

• Conditions: Pulmonary hypertension; Circulatory System; Primary pulmonary hypertension

• Registration Number: ISRCTN12353191
• Lead Sponsor: Georgetown University Institutional Review Board

Brief Summary

2015 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26590128 results

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2014-06-12
• Study Start: 2015-04-23
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

1. Over the age of 18
2. Display a tricuspid regurgitation jet velocity over 2.7 m/s on an inpatient echocardiogram during their current hospital stay

Exclusion Criteria

1. Inability to provide written informed consent
2. Known pulmonary vascular disease
3. Known intolerance to niacin or current treatment with niacin
4. Current treatment with a non-steroidal anti-inflammatory drug (NSAID)
5. Known liver disease (AST/ALT > 3x the upper limit of normal)
6. Patients currently on ventilator support or using a bi-level positive airway pressure (BiPAP) device

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in mean tricuspid regurgitation jet velocity measured in meters/second one hour after study drug administration.

Secondary Outcome Measures

Name	Time	Method
Change in maximum tricuspid regurgitation jet velocity measured in meters/second one hour after study drug administration.