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Clinical Trials/ISRCTN12353191
ISRCTN12353191
Completed
未知

A pilot randomized double-blinded single-dose provocation study on the effect of niacin on pulmonary arterial pressure

Georgetown University Institutional Review Board0 sites49 target enrollmentApril 23, 2015
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ConditionsPulmonary hypertensionCirculatory SystemPrimary pulmonary hypertension

Overview

Phase
未知
Intervention
Not specified
Conditions
Pulmonary hypertension
Sponsor
Georgetown University Institutional Review Board
Enrollment
49
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

2015 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26590128 results

Registry
who.int
Start Date
April 23, 2015
End Date
June 12, 2014
Last Updated
2 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Georgetown University Institutional Review Board

Eligibility Criteria

Inclusion Criteria

  • •1\. Over the age of 18
  • •2\. Display a tricuspid regurgitation jet velocity over 2\.7 m/s on an inpatient echocardiogram during their current hospital stay

Exclusion Criteria

  • •1\. Inability to provide written informed consent
  • •2\. Known pulmonary vascular disease
  • •3\. Known intolerance to niacin or current treatment with niacin
  • •4\. Current treatment with a non\-steroidal anti\-inflammatory drug (NSAID)
  • •5\. Known liver disease (AST/ALT \> 3x the upper limit of normal)
  • •6\. Patients currently on ventilator support or using a bi\-level positive airway pressure (BiPAP) device

Outcomes

Primary Outcomes

Not specified

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