Feasibility of Preoxygenation by Supraglottic Jet Ventilation Before Endotracheal Intubation
- Conditions
- Preoxygenation
- Interventions
- Device: supraglottic jet ventilation
- Registration Number
- NCT04385511
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
The study assumed that supraglottic jet ventilation is an alternative solution as a safe way to do the preoxygenation before endotracheal intubation by contrasting it with mask pressurized ventilation. The investigators also expected that supraglottic jet ventilation won't increase the occurrence of esophageal reflux.
- Detailed Description
The study assumed that supraglottic jet ventilation is an alternative solution as a safe way to do the preoxygenation before endotracheal intubation by contrasting it with mask pressurized ventilation. The investigators also expected that supraglottic jet ventilation won't increase the occurrence of esophageal reflux.
The investigators randomly divided the patients into 2 groups:Group C and Group S.Patients in Group C will be preoxygenation with mask pressurized ventilation while patients in Group S with supraglottic jet ventilation by Wei NASAL JET（WNJ）.The tracheal intubation will be done after the 3 minutes preoxygenation. The investigators will measure the PaCO2 before and after preoxygenation, and the investigators will take the stomach-ultrasonography to find if there are too much gas in the gastro. If pulse oximetry is lower than 95% during the preoxygenation, the investigators will adjust the position of the Wei NASAL JET（WNJ) or use the change the way that the investigators hold the mask or change the pressure of ventilation on the basis of the group.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 68
- scheduled for any surgery under general anesthesia
- adults age range from 18-64 years old
- American Society of Anesthesiologists Physical Status Classification (ASA class) I-II
- voluntary participation in this clinical trail, signed informed consents
- patients with epistaxis, rhinostenosis, the episodes of rhinitis, severe gastroesophageal reflux disease, severe respiratory disease, severe cardiovascular and cerebrovascular disease
- long-term use if anticoagulant drugs
- can't cooperate with intervention
- pulse oximetry <95% with normal respiration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description supraglottic jet ventilation group supraglottic jet ventilation Check blood gas before induction without preoxygen. Take stomach-ultrasound. Induction with Midazolam 0.02 mg/kg, sufentanil 0.3 \~ 0.5 ug/kg, propofol 2-2.5 mg/kg, rocuronium 0.6 mg/kg.After patients fall asleep and can't be woke up ,the investigators will put the Wei NASAL JET（WNJ）into one's nose to give the supraglottic jet ventilation with the driving pressure 0.01-0.03 megapascal (MPa), respiratory rate 15 beats per minute（BPM）, inspiratory/expiratory rate 1-1. 5.Check blood gas,stomach-ultrasound after 3 min, then do the tracheal intubation guided by visual laryngoscope.Stop jet ventilation during intubation.
- Primary Outcome Measures
Name Time Method alveolar oxygen tension（PaO2） baseline (before preoxygenation) The results comes from blood gas analysis
- Secondary Outcome Measures
Name Time Method PaCO2 baseline (before preoxygenation) The results comes from blood gas analysis
gastric antrum cross section baseline (before preoxygenation) The results comes from the ultrasound of gastric
complications 1 day such as nasal bleeding, dry throat itching, sore throat, nausea and vomiting, pressure and other adverse reactions
Trial Locations
- Locations (1)
Peking University People's Hospital
🇨🇳Beijing, Beijing, China